Membrane destabilization by monomeric hIAPP observed by imaging fluorescence correlation spectroscopy

被引：35

作者：

Bag, Nirmalya ^{[1
,2
,3
]}

Ali, Ashraf ^{[4
]}

Chauhan, Virander Singh ^{[4
]}

Wohland, Thorsten ^{[1
,2
,3
]}

Mishra, Aseem ^{[4
]}

机构：

[1] Natl Univ Singapore, Dept Biol Sci, Singapore 117557, Singapore

[2] Natl Univ Singapore, Dept Chem, Singapore 117557, Singapore

[3] Natl Univ Singapore, NUS Ctr Bioimaging Sci CBIS, Singapore 117557, Singapore

[4] Int Ctr Genet Engn & Biotechnol, Malaria Res Grp, New Delhi 110067, India

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 80期

关键词：

ISLET AMYLOID POLYPEPTIDE; DIFFUSION; ORGANIZATION;

D O I：

10.1039/c3cc44880k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Monomeric hIAPP significantly destabilizes both model and live cell membranes by increasing membrane fluidity. This interaction with membranes happens via carpet formation followed by lipid extraction in a concentration dependent manner and thus we propose that hIAPP aggregation prior to membrane interaction may not be necessary for its cytotoxicity.

引用

页码：9155 / 9157

页数：3

共 16 条

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