Acyltransferases for secreted signalling proteins (Review)

被引：42

作者：

Chang, Shu-Chun ^{[1
]}

Magee, Anthony I. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sect Mol Med, Natl Heart & Lung Inst, London SW7 2AZ, England

来源：

MOLECULAR MEMBRANE BIOLOGY | 2009年 / 26卷 / 1-2期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

MBOAT; hedgehog; wingless; Wnt; ghrelin; palmitoylation; acylation; protein acyl transferase; HEPARAN-SULFATE PROTEOGLYCANS; SONIC HEDGEHOG; CHOLESTEROL MODIFICATION; LIPID MODIFICATIONS; DROSOPHILA ORTHOLOG; WNT PROTEINS; CELL-GROWTH; PALMITOYLATION; WINGLESS; MODULATION;

D O I：

10.1080/09687680802706432

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the MBOAT family of multispanning transmembrane enzymes catalyze the acylation of important secreted signalling proteins of the Hedgehog, Wg/Wnt and ghrelin families. Acylation of these substrates occurs during transport through the secretory pathway and plays key roles in their biological activity and spread from producing cells, contributing to the formation of appropriate extracellular concentration gradients. Characterization of these enzymes could lead to their identification as therapeutic targets for diverse human diseases such as cancers, obesity and diabetes.

引用

页码：104 / 113

页数：10

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