The Role of Neuropilin-1-FYN Interaction in Odontoblast Differentiation of Dental Pulp Stem Cells

被引：8

作者：

Song, Yihua ^{[1
]}

Cao, Peipei ^{[1
]}

Gu, Zhifeng ^{[2
]}

Xiao, Jingwen ^{[1
]}

Lian, Min ^{[1
]}

Huang, Dan ^{[1
]}

Xing, Jing ^{[1
]}

Zhang, Ye ^{[3
]}

Feng, Xingmei ^{[1
]}

Wang, Chenfei ^{[1
]}

机构：

[1] Nantong Univ, Affiliated Hosp, Dept Stomatol, Prov Key Lab Inflammat & Mol Drug Target, 20 Xisi Rd, Nantong 226001, Jiangsu, Peoples R China

[2] Nantong Univ, Dept Rheumatol, Affiliated Hosp, Nantong, Peoples R China

[3] Qidong Peoples Hosp, Dept Stomatol, Nantong, Peoples R China

来源：

CELLULAR REPROGRAMMING | 2018年 / 20卷 / 02期

关键词：

neuropilin-1; FYN; dental pulp stem cells; odontoblast differentiation; nuclear factor kappa B; CELLULAR PROLIFERATION; PLASMINOGEN-ACTIVATOR; FYN; RECOGNITION; OSTEOCALCIN; EXPRESSION; MOLECULE; BINDING; SRC;

D O I：

10.1089/cell.2017.0041

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Abnormal odontoblast differentiation of dental pulp stem cells (DPSCs) caused by inflammation is closely related to the development of dental caries. Neuropilin-1 (NRP1) is one of the members of neuropilin family. It can combine with disparate ligands involved in regulating cell differentiation. FYN belongs to the protein-tyrosine kinase family, which has been implicated in the control of cell growth, and the effect can be further strengthened by inflammatory factors. In our studies, we verified that NRP1 can form complexes with FYN and have the correlation changes in odontoblast differentiation of DPSCs. Therefore, we surmise that in the progress of dental caries, NRP1 interacts with FYN, by expanding inflammation and inhibition of odontoblast differentiation of DPSCs through nuclear factor kappa B (NF-B) signaling pathway. In this subject, we first investigated the expression and interaction of NRP1 and FYN in DPSCs. And then, we researched the effect of this complex controlling downstream signal pathway in normal or inflammation stimulated DPSCs. Finally, we analyzed the relationship between this role and odontoblast differentiation of DPSCs. This research will provide the molecular mechanism of inflammation factors of dental caries through activating NF-B signal regulating odontoblast differentiation in DPSCs for finding new potential drug targets for the clinical treatment of dental caries.

引用

页码：117 / 126

页数：10

共 29 条

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