Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines

被引：94

作者：

Arachchige, Pandula T. Kirinde ^{[1
]}

Yi, Chae S. ^{[1
]}

机构：

[1] Marquette Univ, Dept Chem, Milwaukee, WI 53201 USA

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 09期

基金：

美国国家科学基金会;

关键词：

OXIDATIVE SYNTHESIS; O-AMINOBENZAMIDES; QUINAZOLIN-4(3H)-ONES; DOXAZOSIN; ALCOHOLS;

D O I：

10.1021/acs.orglett.9b01082

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products. The deaminative coupling reaction of 2-aminobenzamides with amines led to the efficient formation of quinazolinone products. The catalytic coupling method provides an efficient synthesis of quinazoline and quinazolinone derivatives without using any reactive reagents or forming any toxic byproducts.

引用

页码：3337 / 3341

页数：5

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