Elastomeric recombinant protein-based biomaterials

被引：76
作者：
Annabi, Nasim [1 ,2 ,3 ]
Mithieux, Suzanne M. [4 ]
Camci-Unal, Gulden [1 ,2 ]
Dokmeci, Mehmet R. [1 ,2 ]
Weiss, Anthony S. [4 ,5 ,6 ]
Khademhosseini, Ali [1 ,2 ,3 ]
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Ctr Biomed Engn,Dept Med, Boston, MA 02139 USA
[2] MIT, Harvard MIT Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[3] Harvard Univ, Wyss Inst Biol Inspired Engn, Cambridge, MA 02139 USA
[4] Univ Sydney, Sch Mol Biosci, Sydney, NSW 2006, Australia
[5] Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia
[6] Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia
来源：
BIOCHEMICAL ENGINEERING JOURNAL | 2013年 / 77卷
基金：
美国国家卫生研究院; 美国国家科学基金会; 英国医学研究理事会; 澳大利亚研究理事会;
关键词：
Elastomer; Tropoelastin; Elastin-like polypeptides; Biomaterials; Elasticity; ELASTIN-LIKE POLYPEPTIDE; CROSS-LINKING; MECHANICAL-PROPERTIES; EXTRACELLULAR-MATRIX; HUMAN TROPOELASTIN; ESCHERICHIA-COLI; BLOCK-COPOLYMERS; BINDING PROTEIN; FIBER FORMATION; VASCULAR GRAFT;
D O I：
10.1016/j.bej.2013.05.006
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Elastomeric protein-based biomaterials, produced from elastin derivatives, are widely investigated as promising tissue engineering scaffolds due to their remarkable properties including substantial extensibility, long-term stability, self-assembly, high resilience upon stretching, low energy loss, and excellent biological activity. These elastomers are processed from different sources of soluble elastin such as animal-derived soluble elastin, recombinant human tropoelastin, and elastin-like polypeptides into various forms including three dimensional (3D) porous hydrogels, elastomeric films, and fibrous electrospun scaffolds. Elastin-based biomaterials have shown great potential for the engineering of elastic tissues such as skin, lung and vasculature. In this review, the synthesis and properties of various elastin-based elastomers with their applications in tissue engineering are described. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：110 / 118
页数：9
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