Quality of life following completion of treatment for adult acute lymphoblastic leukemia with a pediatric-based protocol

被引：11
作者：
Liew, Elena [1 ]
Thyagu, Santhosh [1 ]
Atenafu, Eshetu G. [2 ]
Alibhai, Shabbir M. H. [3 ]
Brandwein, Joseph M. [1 ]
机构：
[1] Univ Toronto, Dept Med Oncol & Hematol, Princess Margaret Canc Ctr, Toronto, ON, Canada
[2] Univ Toronto, Dept Biostat, Princess Margaret Canc Ctr, Toronto, ON, Canada
[3] Univ Toronto, Dept Med, Univ Hlth Network, Toronto, ON, Canada
来源：
LEUKEMIA RESEARCH | 2013年 / 37卷 / 12期
关键词：
Acute lymphoblastic leukemia; Leukemia; Quality of life; Chemotherapy; EUROPEAN-ORGANIZATION; CANCER-PATIENTS; EORTC QLQ-C30; DEPRESSION; FATIGUE; QUESTIONNAIRE; PREVALENCE; SYMPTOMS; OUTCOMES; TRIALS;
D O I：
10.1016/j.leukres.2013.09.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Using multiple validated self-report instruments, we evaluated the health-related quality of life (HRQoL) of 29 adult ALL patients a median of 28 months after completing a pediatric-based treatment regimen. Global health was similar to normative data, but leukemia survivors had lower cognitive and social function, and reported more financial difficulty. Fatigue and pain affected 83% and 53% of patients, respectively, and both showed significant inverse correlation with overall health and all functional scales. Vincristinerelated peripheral neuropathy was reported by 43%. Although therapy-related symptoms were persistent, long-term ALL survivors have a global HRQoL similar to the general population. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1632 / 1635
页数：4
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