Quality of life following completion of treatment for adult acute lymphoblastic leukemia with a pediatric-based protocol

被引：11

作者：

Liew, Elena ^{[1
]}

Thyagu, Santhosh ^{[1
]}

Atenafu, Eshetu G. ^{[2
]}

Alibhai, Shabbir M. H. ^{[3
]}

Brandwein, Joseph M. ^{[1
]}

机构：

[1] Univ Toronto, Dept Med Oncol & Hematol, Princess Margaret Canc Ctr, Toronto, ON, Canada

[2] Univ Toronto, Dept Biostat, Princess Margaret Canc Ctr, Toronto, ON, Canada

[3] Univ Toronto, Dept Med, Univ Hlth Network, Toronto, ON, Canada

来源：

LEUKEMIA RESEARCH | 2013年 / 37卷 / 12期

关键词：

Acute lymphoblastic leukemia; Leukemia; Quality of life; Chemotherapy; EUROPEAN-ORGANIZATION; CANCER-PATIENTS; EORTC QLQ-C30; DEPRESSION; FATIGUE; QUESTIONNAIRE; PREVALENCE; SYMPTOMS; OUTCOMES; TRIALS;

D O I：

10.1016/j.leukres.2013.09.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using multiple validated self-report instruments, we evaluated the health-related quality of life (HRQoL) of 29 adult ALL patients a median of 28 months after completing a pediatric-based treatment regimen. Global health was similar to normative data, but leukemia survivors had lower cognitive and social function, and reported more financial difficulty. Fatigue and pain affected 83% and 53% of patients, respectively, and both showed significant inverse correlation with overall health and all functional scales. Vincristinerelated peripheral neuropathy was reported by 43%. Although therapy-related symptoms were persistent, long-term ALL survivors have a global HRQoL similar to the general population. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：1632 / 1635

页数：4

共 27 条

[1] THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].