Inhibiting Human Breast Cancer Cell Growth In Vitro of a Novel Heterocycles Compound

被引：0

作者：

Kong, Ying ^{[1
]}

Yang, Chong ^{[1
]}

Su, Yanyan ^{[1
]}

Ying, Jiake ^{[1
]}

Ye, Yu ^{[1
]}

机构：

[1] Hangzhou Red Cross Hosp, Dept Gen Surg, Hangzhou, Zhejiang, Peoples R China

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 12期

关键词：

anti-breast cancer; heterocycles; single crystal; SORAFENIB; HPLC;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The new heterocycles compound N-(4-bromo-3-(trifluoromethyl) phenyl)-N'-(4-(2-(N-methylcarbamoyl)- 4-pyridyloxy)phenyl)urea (3), designed using 4-chloro-N-methyl-2-pyridinecarboxamide (1) as start material, was successfully obtained via multiple synthesis route and finally characterized by IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. In addition, the anti-breast cancer effects of compound 3 was studied on three human breast cancer cell lines including SKBr-3, ZR-75-30 and MCF7. The results showed that compared with the positive reference drug carboplatin, compound 3 displayed efficient anti-breast cancer activity.

引用

页码：2369 / 2373

页数：5

共 45 条

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