Inhibiting Human Breast Cancer Cell Growth In Vitro of a Novel Heterocycles Compound

The new heterocycles compound N-(4-bromo-3-(trifluoromethyl) phenyl)-N'-(4-(2-(N-methylcarbamoyl)- 4-pyridyloxy)phenyl)urea (3), designed using 4-chloro-N-methyl-2-pyridinecarboxamide (1) as start material, was successfully obtained via multiple synthesis route and finally characterized by IR, H-1 NMR, HRMS, and single crystal X-ray crystallography. In addition, the anti-breast cancer effects of compound 3 was studied on three human breast cancer cell lines including SKBr-3, ZR-75-30 and MCF7. The results showed that compared with the positive reference drug carboplatin, compound 3 displayed efficient anti-breast cancer activity.