Update on Kawasaki disease: Epidemiology, aetiology and pathogenesis

被引：53
作者：
Yim, Deane [1 ]
Curtis, Nigel [2 ,3 ,4 ]
Cheung, Michael [1 ,2 ,3 ]
Burgner, David [2 ,3 ]
机构：
[1] Univ Melbourne, Dept Cardiol, Melbourne, Vic, Australia
[2] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia
[3] Royal Childrens Hosp Melbourne, Murdoch Childrens Res Inst, Melbourne, Vic, Australia
[4] Royal Childrens Hosp Melbourne, Infect Dis Unit, Dept Gen Med, Melbourne, Vic, Australia
来源：
JOURNAL OF PAEDIATRICS AND CHILD HEALTH | 2013年 / 49卷 / 09期
关键词：
aetiology; Kawasaki disease; pathogenesis; review; TOXIC-SHOCK-SYNDROME; STAPHYLOCOCCUS-AUREUS; MATRIX-METALLOPROTEINASE-9; SUSCEPTIBILITY; ASSOCIATION; GENE; POLYMORPHISM; ACTIVATION; EXPRESSION; ETHNICITY;
D O I：
10.1111/jpc.12172
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Kawasaki disease is an acute systemic vasculitis predominantly affecting young children. It is due to an abnormal host response to as yet unidentified infectious trigger(s). Kawasaki disease may cause coronary artery damage, long-term cardiovascular morbidity and occasionally mortality, especially if the diagnosis is missed or timely treatment is not given. This is the first of two updates on Kawasaki disease. Here we review recent advances in epidemiology, possible aetiologies, host susceptibility and pathogenesis of this fascinating condition.
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页码：704 / 708
页数：5
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