Omega-3 polyunsaturated fatty acid docosahexaenoic acid and its role in exhaustive-exercise-induced changes in female rat ovulatory cycle

被引：6
作者：
Mostafa, Abeer F. [1 ]
Samir, Shereen M. [1 ]
Nagib, R. M. [2 ]
机构：
[1] Mansoura Univ, Fac Med, Dept Med Physiol, Mansoura, Egypt
[2] Mansoura Univ, Fac Med, Dept Pathol, Mansoura, Egypt
来源：
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2018年 / 96卷 / 04期
关键词：
exhaustive exercise; cortisol; omega-3 polyunsaturated fatty acid; docosahexaenoic acid; caspase-3; estrous cycles; PITUITARY-ADRENAL-AXIS; ALPHA-LINOLENIC ACID; OXIDATIVE STRESS; GENE-EXPRESSION; DAIRY-COWS; OVARIAN; OMEGA-3-FATTY-ACIDS; DEPRESSION; IMPACT; DIET;
D O I：
10.1139/cjpp-2017-0354
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Exhaustive exercises can cause delayed menarche or menstrual cycle irregularities in females. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) are incorporated into a wide range of benefits in many physiological systems. Our work aimed to assess the role of omega-3 PUFA docosahexaenoic acid (DHA) on the deleterious effects of exhaustive exercise on the female reproductive system in rats. Virgin female rats were randomly divided into 4 groups (12 rats in each): control group, omega-3 group treated with DHA, exhaustive exercise group, and exhaustive exercised rats treated with DHA. Omega-3 was given orally to the rats once daily for 4 estrous cycles. Exhaustive exercises revealed lower levels in progesterone and gonadotropins together with histopathological decrease in number of growing follicles and corpora lutea. Moreover, the exercised rats showed low levels of ovarian antioxidants with high level of caspase-3 and plasma cortisol level that lead to disruption of hypothalamic-pituitary-gonadal axis. omega-3 PUFA DHA has beneficial effects on the number of newly growing follicles in both sedentary and exercised rats with decreasing the level of caspase-3 and increasing the antioxidant activity in ovaries. Exhaustive exercises can cause ovulatory problems in female rats that can be improved by omega-3 supplementation.
引用
收藏
页码：395 / 403
页数：9
相关论文
共 53 条
[41]   Oxidative stress and antioxidants: exposure and impact on female fertility [J].
Ruder, Elizabeth H. ;
Hartman, Terryl J. ;
Blumberg, Jeffrey ;
Goldman, Marlene B. .
HUMAN REPRODUCTION UPDATE, 2008, 14 (04) :345-357
[42]   Potential role of dietary ω-3 essential fatty acids on some oxidant/antioxidant parameters in rats' corpus striatum [J].
Sarsilmaz, M ;
Songur, A ;
Özyurt, H ;
Kus, I ;
Özen, OA ;
Özyurt, B ;
Sögüt, S ;
Akyol, Ö .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2003, 69 (04) :253-259
[43]   The regulatory role of dietary ω-3 essential fatty acids on oxidant/antioxidant balance in rat hippocampus [J].
Sarsimaz, M ;
Songur, A ;
Kus, I ;
Ozyurt, B ;
Gulec, M ;
Sogut, S ;
Ilhan, A ;
Akyol, O .
NEUROSCIENCE RESEARCH COMMUNICATIONS, 2003, 33 (02) :114-123
[44]   Cytokines and major depression [J].
Schiepers, OJG ;
Wichers, MC ;
Maes, M .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2005, 29 (02) :201-217
[45]   Relative impact of oxidative stress on male reproductive function [J].
Sikka, SC .
CURRENT MEDICINAL CHEMISTRY, 2001, 8 (07) :851-862
[46]   Omega-3 fatty acids in inflammation and autoimmune diseases [J].
Simopoulos, AP .
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, 2002, 21 (06) :495-505
[47]   Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies [J].
Tapiero, H ;
Ba, GN ;
Couvreur, P ;
Tew, KD .
BIOMEDICINE & PHARMACOTHERAPY, 2002, 56 (05) :215-222
[48]   Diets enriched in unsaturated fatty acids enhance early embryonic development in lactating Holstein cows [J].
Thangavelu, G. ;
Colazo, M. G. ;
Ambrose, D. J. ;
Oba, M. ;
Okine, E. K. ;
Dyck, M. K. .
THERIOGENOLOGY, 2007, 68 (07) :949-957
[49]  
Trujillo EP, 1995, J REPROD FERTIL, V105, P197, DOI 10.1530/jrf.0.1050197
[50]   Animal Models in the Study of Exercise-Induced Cardiac Hypertrophy [J].
Wang, Y. ;
Wisloff, U. ;
Kemi, O. J. .
PHYSIOLOGICAL RESEARCH, 2010, 59 (05) :633-644
123456