Studies on nucleosides .6. Stereoselective synthesis of triazoline-thione nucleosides

被引：0

作者：

Chen, HM ^{[1
]}

Zhang, J ^{[1
]}

Mao, JM ^{[1
]}

Cai, MS ^{[1
]}

机构：

[1] BEIJING MED UNIV,SCH PHARMACEUT SCI,DEPT ORGAN CHEM,BEIJING 100083,PEOPLES R CHINA

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 1996年 / 12卷 / 03期

关键词：

nucleoside; nicotinic acid; heterocyclic compound;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of heterocyclic compounds of triazole thione substituted by tetrazole ( I) were prepared using nicotinic acid as starting material through several steps. They reacted with 1-O-trifluoroacetyl-2,3,5-O-tri-benzoyl-beta-D-ribofuranose (II) in anhydrous CH2Cl2 at room temperature in the presence of BF3 . Et(2)O to give nine new nucleosides, named as 3-[5-(3-pyridyl)-tetrazol-2-yl-methylene]-4-aryl-1,2, 4-triazole-5-(4H)-thione-2,3,5-O-tribenzoyl-beta-D-ribo-furanoside (II) (Ar = C6H5, o-MeC(6)H(4), m-MeC(6)H(4), p-MeC(6)H(4), o-MeOC(6)H(4), p-MeOC(6)H(4), p-EtOC(6)H(3), 3, 4-Me(2)C(6)H(4), alpha-C10H7). The structures and compositions were characterized by means of elemental analysis and spectroscopic methods.

引用

页码：258 / 263

页数：6

共 11 条

[1] STEREOSELECTIVE AND MILD METHOD FOR THE SYNTHESIS OF C-D-GLUCOSYLARENES IN HIGH-YIELD .14.
CAI, MS
QIU, DX
[J]. CARBOHYDRATE RESEARCH, 1989, 191 (01) : 125 - 129
[2] CAI MS, 1990, SYNTHETIC COMMUN, V20, P943
[3] CAI MS, 1993, ACTA CHIM SINICA CH, V51, P1010
[4] CHEN HM, 1994, CHEM J CHINESE U, V15, P705
[5] FONG XM, 1989, CHEM J CHINESE U, V12, P1326
[6] MAO JM, 1994, CHINESE CHEM LETT, V5, P465
[7] PATHAK RB, 1970, J MED CHEM, V13, P275
[8] REMAN K, 1980, HETEROCYCL CHEM, V17, P1137
[9] VACUUM LIQUID-CHROMATOGRAPHY - ALTERNATIVE TO COMMON CHROMATOGRAPHIC METHODS
TARGETT, NM
KILCOYNE, JP
GREEN, B
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1979, 44 (26) : 4962 - 4964
[10] ZHANG LX, 1990, CHEM J CHINESE U, V11, P148

← 1 2 →