Design of controlled release systems for THEDES-Therapeutic deep eutectic solvents, using supercritical fluid technology

被引：148

作者：

Aroso, Ivo M. ^{[1
,2
]}

Craveiro, Rita ^{[3
]}

Rocha, Angelo ^{[4
]}

Dionisio, Madalena ^{[3
]}

Barreiros, Susana ^{[3
]}

Reis, Rui L. ^{[1
,2
]}

Paiva, Alexandre ^{[3
]}

Duarte, Ana Rita C. ^{[1
,2
]}

机构：

[1] Univ Minho, Res Grp Biomat Biodegradables & Biomimet 3Bs, Headquarters European Inst Excellence Tissue Engn, P-4805017 Barco, Guimaraes, Portugal

[2] ICVS 3Bs PT Govt Associated Lab, Braga, Portugal

[3] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, REQUIMTE CQFB, P-2829516 Caparica, Portugal

[4] Univ Lisbon, Inst Super Tecn, Dept Bioengn, IBB Inst Bioengn & Biosci, P-1049001 Lisbon, Portugal

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2015年 / 492卷 / 1-2期

关键词：

Therapeutic deep eutectic solvents; Supercritical carbon dioxide; Drug delivery systems; Biodegradable polymers; Ibuprofen; SUBCRITICAL CO2; IONIC LIQUIDS; DRUG; DELIVERY; SCAFFOLDS; POLYMERS; COMPOSITES; MIXTURES; PHASE;

D O I：

10.1016/j.ijpharm.2015.06.038

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Deep eutectic solvents (DES) can be formed by bioactive compounds or pharmaceutical ingredients. A therapeutic DES (THEDES) based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC). A controlled drug delivery system was developed by impregnating a starch: poly-e-caprolactone polymeric blend (SPCL 30: 70) with the menthol: ibuprofen THEDES in different ratios (10 and 20 wt%), after supercritical fluid sintering at 20 MPa and 50 degrees C. The morphological characterization of SPCL matrices impregnated with THEDES was performed by scanning electron microscopy (SEM) and microcomputed tomography (micro-CT). Drug release studies were carried out in a phosphate buffered saline. The results obtained provide important clues for the development of carriers for the sustainable delivery of bioactive compounds. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：73 / 79

页数：7

共 37 条

[1] Deep eutectic solvents formed between choline chloride and carboxylic acids: Versatile alternatives to ionic liquids [J].

Abbott, AP ;

Boothby, D ;

Capper, G ;

Davies, DL ;

Rasheed, RK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (29) :9142-9147

[2] PDLLA enriched with ulvan particles as a novel 3D porous scaffold targeted for bone engineering [J].

Alves, Anabela ;

Duarte, Ana Rita C. ;

Mano, Joao F. ;

Sousa, Rui A. ;

Reis, Rui L. .

JOURNAL OF SUPERCRITICAL FLUIDS, 2012, 65 :32-38

[3] Starch-poly-N"-caprolactone Microparticles Reduce the Needed Amount of BMP-2 [J].

Balmayor, E. R. ;

Feichtinger, G. A. ;

Azevedo, H. S. ;

van Griensven, M. ;

Reis, R. L. .

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2009, 467 (12) :3138-3148

[4] Subcritical CO2 sintering of microspheres of different polymeric materials to fabricate scaffolds for tissue engineering [J].

Bhamidipati, Manjari ;

Sridharan, BanuPriya ;

Scurto, Aaron M. ;

Detamore, Michael S. .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2013, 33 (08) :4892-4899

[5] Pharmaceutically active ionic liquids with solids handling, enhanced thermal stability, and fast release [J].

Bica, Katharina ;

Rodriguez, Hector ;

Gurau, Gabriela ;

Cojocaru, O. Andreea ;

Riisager, Anders ;

Fehrmann, Rasmus ;

Rogers, Robin D. .

CHEMICAL COMMUNICATIONS, 2012, 48 (44) :5422-5424

[6] Molecular motions in amorphous ibuprofen as studied by broadband dielectric spectroscopy [J].

Bras, Ana R. ;

Noronha, Joao P. ;

Antunes, Alexandra M. M. ;

Cardoso, Maria M. ;

Schoenhals, Andreas ;

Affouard, Frederic ;

Dionisio, Madalena ;

Correia, Natalia T. .

JOURNAL OF PHYSICAL CHEMISTRY B, 2008, 112 (35) :11087-11099

[7] Deep-eutectic solvents playing multiple roles in the synthesis of polymers and related materials [J].

Carriazo, Daniel ;

Concepcion Serrano, Maria ;

Concepcion Gutierrez, Maria ;

Luisa Ferrer, Maria ;

del Monte, Francisco .

CHEMICAL SOCIETY REVIEWS, 2012, 41 (14) :4996-5014

[8] Insights into the crystal structure, polymorphism and thermal behavior of menthol optical isomers and racemates [J].

Corvis, Yohann ;

Negrier, Philippe ;

Massip, Stephane ;

Leger, Jean-Michel ;

Espeau, Philippe .

CRYSTENGCOMM, 2012, 14 (20) :7055-7064

[9] Modeling and comparison of dissolution profiles [J].

Costa, P ;

Manuel, J ;

Lobo, S .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2001, 13 (02) :123-133

[10] Starch-based polymer-IL composites formed by compression moulding and supercritical fluid foaming for self-supported conductive materials [J].

Craveiro, R. ;

Martins, M. ;

Santos, G. B. ;

Correia, N. ;

Dionisio, M. ;

Barreiros, S. ;

Duarte, A. R. C. ;

Reis, R. L. ;

Paiva, A. .

RSC ADVANCES, 2014, 4 (33) :17161-17170

← 1 2 3 4 →