Purpura fulminans, venous thrombosis and constitutional thrombophilia in an infant

被引：1
作者：
Fadil, F. [1 ]
Elfatoiki, F. [2 ]
Mortaji, K. [1 ]
Lasry, F. [1 ,2 ]
Itri, M. [1 ]
Khadir, K. [2 ]
Benchikhi, H. [2 ]
Sarbati, N. [3 ]
Nadifi, S. [3 ]
机构：
[1] CHU Ibn Rochd, Hop Enfant, Serv Pediat 3, Casablanca, Morocco
[2] CHU Ibn Rochd, Serv Dermatol, Casablanca, Morocco
[3] Fac Med, Genet Lab, Casablanca, Morocco
来源：
ARCHIVES DE PEDIATRIE | 2013年 / 20卷 / 05期
关键词：
FACTOR-V-LEIDEN; PROTEIN-C; PROTHROMBIN G20210A; VEIN THROMBOSIS; GENE; DEFICIENCY; INFECTION; CHILDREN; MTHFR; RISK;
D O I：
10.1016/j.arcped.2013.02.077
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The association of idiopathic purpura fulminans (PF) and venous thrombosis (VT) seldom reveals constitutional thrombophilia in an infant. We report a case of PF in an 18-month-old infant. Laboratory tests showed disseminated intravascular coagulation (DIVC) with normal rates of C and S proteins and antithrombin. The echo-Doppler examination conveyed venous thrombosis of the lower limbs, while the genetic study showed heterozygous mutation of Factor II (G 20210A). Precocious and multidisciplinary management included frozen fresh plasma supplementation and necrosectomy with skin grafts. The diagnosis and therapeutic problems posed by PF combined with deep venous thrombosis are discussed. (c) 2013 Published by Elsevier Masson SAS.
引用
收藏
页码：499 / 502
页数：4
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