Metal-Free Oxidative Spirocyclization of Hydroxymethylacrylamide with 1,3-Dicarbonyl Compounds: A New Route to Spirooxindoles

被引：117

作者：

Wang, Hua

Guo, Li-Na ^{[1
]}

Duan, Xin-Hua

机构：

[1] Xi An Jiao Tong Univ, Sch Sci, Dept Chem, Xian 710049, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 20期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; ACTIVATED ALKENES; H FUNCTIONALIZATION; 3-COMPONENT SYNTHESIS; RADICAL CYCLIZATION; CONCISE SYNTHESIS; C(SP3)H BOND; OXINDOLES; CONSTRUCTION; ACRYLAMIDES;

D O I：

10.1021/ol402473m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A metal-free oxidative spirocyclization of hydroxymethylacrylamide with 1,3-dicarbonyl compounds is described. The reaction proceeds through tandem dual C-H functionalization and intramolecular dehydration, in which two new C-C bonds and one C-O bond were formed. This method affords a novel and straightforward access to various spirooxindoles under mild conditions.

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收藏

页码：5254 / 5257

页数：4

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