Ring formylation of bromobenzoate esters by direct metalation

被引：4

作者：

Kende, AS ^{[1
]}

Zhong, M ^{[1
]}

机构：

[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA

来源：

SYNTHETIC COMMUNICATIONS | 1999年 / 29卷 / 19期

关键词：

D O I：

10.1080/00397919908085967

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A study on the synthesis of a benzaldehyde containing an ester function directly from tert-butyl 4-lithiobenzate was described. t-Butyl 4-bromobenzoate reacted with butyllithium at -78 degrees C in THF, followed by immediate addition of DMF to give the desired benzaldehyde in moderate yield. The scope of this reaction was examined.

引用

页码：3401 / 3407

页数：7

共 7 条

[1] Stereoselective conjugate addition reactions of α,β-unsaturated tert-butyl esters with aryllithium reagents [J].