Neuroprotection by curcumin: A review on brain delivery strategies

被引：64
作者：
Askarizadeh, Anis [1 ]
Barreto, George E. [2 ,3 ]
Henney, Neil C. [4 ]
Majeed, Muhammed [5 ]
Sahebkar, Amirhossein [6 ,7 ,8 ]
机构：
[1] Mashhad Univ Med Sci, Nanotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran
[2] Univ Limerick, Dept Biol Sci, Limerick, Ireland
[3] Univ Autonoma Chile, Inst Ciencias Biomed, Santiago, Chile
[4] Liverpool John Moores Univ, Pharm & Biomol Sci, Liverpool, Merseyside, England
[5] Sabinsa Corp, East Windsor, NJ USA
[6] FDA, Halal Res Ctr IRI, Tehran, Iran
[7] Mashhad Univ Med Sci, Biotechnol Res Ctr, Pharmaceut Technol Inst, Mashhad, Razavi Khorasan, Iran
[8] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Razavi Khorasan, Iran
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2020年 / 585卷
关键词：
Neurodegeneration; Curcumin; Blood-brain barrier; Nanotechnology; Drug delivery; SOLID LIPID NANOPARTICLES; IN-VITRO EVALUATION; INTRANASAL MUCOADHESIVE MICROEMULSIONS; LOADED PLGA NANOPARTICLES; BLOCK-COPOLYMER MICELLES; LOW-DENSITY-LIPOPROTEIN; DRUG-DELIVERY; MAGNETIC NANOPARTICLES; POLYMERIC NANOPARTICLES; ANTIINFLAMMATORY DRUGS;
D O I：
10.1016/j.ijpharm.2020.119476
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Neurodegenerative diseases are a major global public health concern in the elderly population but therapeutic options are limited. Curcumin is a hydrophobic polyphenol extracted from the dried rhizomes of Curcuma longa L. and shows good potential for the treatment of neurodegenerative diseases and brain tumors. The blood-brain barrier (BBB) is the major obstacle for the delivery of curcumin into the brain, limiting its therapeutic potential. The development of promising approaches to facilitate curcumin transportation across the BBB may resolve some of the problems associated with drug delivery. Studies have shown nano delivery of curcumin can improve a number of outcome measures in neurodegenerative diseases. The present review highlights current and emerging strategies to facilitate curcumin permeation across the BBB for the treatment of various neurodegenerative diseases.
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页数：19
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