Antioxidant Stress and Anti-Inflammation of PPARα on Warm Hepatic Ischemia-Reperfusion Injury

被引：15
作者：
Gao, Zhixin [1 ]
Li, Yuan-Hai [1 ]
机构：
[1] Anhui Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Hefei 230022, Peoples R China
来源：
PPAR RESEARCH | 2012年 / 2012卷
关键词：
NF-KAPPA-B; PROLIFERATOR-ACTIVATED RECEPTORS; PERFUSED-RAT-LIVER; NECROSIS-FACTOR-ALPHA; REACTIVE OXYGEN; ISCHEMIA/REPERFUSION INJURY; OXIDATIVE STRESS; KUPFFER CELLS; SUPEROXIDE GENERATION; ADHESION MOLECULE-1;
D O I：
10.1155/2012/738785
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem. Minimizing the adverse effect of ischemia-reperfusion injury after liver surgery or trauma is an urgent need. It has been proved that besides the effect of regulating the lipid and lipoprotein metabolism, PPAR alpha also undertakes the task of organ protection. In this paper, related literature has been summarized and we come to the conclusion that administration of PPAR alpha agonists can strengthen the antioxidant and anti-inflammation defense system by the upregulation of the expression of antioxidant enzymes and inhibition of NF-kappa B activity. This may provide a potential clinical treatment for hepatic ischemia-reperfusion injury.
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页数：8
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