Twin screw granulation: Steps in granule growth

被引：79

作者：

Dhenge, Ranjit M. ^{[1
]}

Cartwright, James J. ^{[2
]}

Hounslow, Michael J. ^{[1
]}

Salman, Agba D. ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem & Biol Engn, Sheffield S1 3JD, S Yorkshire, England

[2] GlaxoSmithKline, Prod Dev, Stevenage SG1 2NY, Herts, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2012年 / 438卷 / 1-2期

关键词：

Twin screw; Wet granulation; Viscosity; Growth; Mechanism; WET GRANULATION; MELT GRANULATION; BREAKAGE; PARTICLE; KINETICS; IMPACT; MIXER;

D O I：

10.1016/j.ijpharm.2012.08.049

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present work focuses on the study of the progression of granules in different compartments along the length of screws in a twin screw granulator (TSG). The effects of varying powder feed rate; liquid to solid ratio and viscosity of granulation liquid on properties of granules was studied. The bigger granules produced at the start of the process were found to change in terms of size, shape and strength along the screw length at all the conditions investigated. The granules became more spherical and their strength increased along the screw length. Tracer granules were also introduced in order to understand the role of kneading and conveying elements in the TSG. The kneading elements promoted consolidation and breakage while the conveying elements led to coalescence, breakage and some consolidation. The results presented here help to provide a qualitative and quantitative understanding of the twin screw granulation process. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：20 / 32

页数：13

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