Evolution and typing of IncC plasmids contributing to antibiotic resistance in Gram-negative bacteria

被引:64
|
作者
Ambrose, Stephanie J. [1 ]
Harmer, Christopher J. [1 ]
Hall, Ruth M. [1 ]
机构
[1] Univ Sydney, Sch Life & Environm Sci, Mol Biosci Bldg G08, Sydney, NSW 2006, Australia
基金
澳大利亚国家健康与医学研究理事会;
关键词
Evolution; IncC; Antibiotic resistance; Typing; COMPLETE NUCLEOTIDE-SEQUENCE; METALLO-BETA-LACTAMASE; KLEBSIELLA-PNEUMONIAE; ESCHERICHIA-COLI; SALMONELLA-ENTERICA; MULTIDRUG-RESISTANCE; INCA/C PLASMID; VIBRIO-CHOLERAE; R-FACTORS; CARRYING BLA(NDM-1);
D O I
10.1016/j.plasmid.2018.08.001
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The large, broad host range IncC plasmids are important contributors to the spread of key antibiotic resistance genes and over 200 complete sequences of IncC plasmids have been reported. To track the spread of these plasmids accurate typing to identify the closest relatives is needed. However, typing can be complicated by the high variability in resistance gene content and various typing methods that rely on features of the conserved backbone have been developed. Plasmids can be broadly typed into two groups, type 1 and type 2, using four features that differentiate the otherwise closely related backbones. These types are found in many different countries in bacteria from humans and animals. However, hybrids of type 1 and type 2 are also occasionally seen, and two further types, each represented by a single plasmid, were distinguished. Generally, the antibiotic resistance genes are located within a small number of resistance islands, only one of which, ARI-B, is found in both type 1 and type 2. The introduction of each resistance island generates a new lineage and, though they are continuously evolving via the loss of resistance genes or introduction of new ones, the island positions serve as valuable lineage-specific markers. A current type 2 lineage of plasmids is derived from an early type 2 plasmid but the sequences of early type 1 plasmids include features not seen in more recent type 1 plasmids, indicating a shared ancestor rather than a direct lineal relationship. Some features, including ones essential for maintenance or for conjugation, have been examined experimentally.
引用
收藏
页码:40 / 55
页数:16
相关论文
共 50 条
  • [1] Evaluation of Antibiotic Resistance Mechanisms in Gram-Negative Bacteria
    Gauba, Anusha
    Rahman, Khondaker Miraz
    ANTIBIOTICS-BASEL, 2023, 12 (11):
  • [2] Analysis of antibiotic resistance regions in Gram-negative bacteria
    Partridge, Sally R.
    FEMS MICROBIOLOGY REVIEWS, 2011, 35 (05) : 820 - 855
  • [3] Evolution and dissemination of L and M plasmid lineages carrying antibiotic resistance genes in diverse Gram-negative bacteria
    Blackwell, Grace A.
    Doughty, Emma L.
    Moran, Robert A.
    PLASMID, 2021, 113
  • [4] RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance
    Colclough, Abigail L.
    Alav, Ilyas
    Whittle, Emily E.
    Pugh, Hannah L.
    Darby, Elizabeth M.
    Legood, Simon W.
    McNeil, Helen E.
    Blair, Jessica M. A.
    FUTURE MICROBIOLOGY, 2020, 15 (02) : 143 - 157
  • [5] Evolution of β-lactams resistance in Gram-negative bacteria in Tunisia
    Chouchani, Chedly
    Marrakchi, Rim
    El Salabi, Allaaeddin
    CRITICAL REVIEWS IN MICROBIOLOGY, 2011, 37 (03) : 167 - 177
  • [6] Detection of resistance phenotypes in gram-negative bacteria
    Navarro, Ferran
    Calvo, Jorge
    Canton, Rafael
    Fernandez-Cuenca, Felipe
    Mirelis, Beatriz
    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2011, 29 (07): : 524 - 534
  • [7] Transfer dynamics of antimicrobial resistance among gram-negative bacteria
    Wang, Bangjuan
    Farhan, Muhammad Haris Raza
    Yuan, Linlin
    Sui, Yuxin
    Chu, Jinhua
    Yang, Xiaohan
    Li, Yuxin
    Huang, Lingli
    Cheng, Guyue
    SCIENCE OF THE TOTAL ENVIRONMENT, 2024, 954
  • [8] Antibiotic-induced stress responses in Gram-negative bacteria and their role in antibiotic resistance
    Brand, Chante
    Newton-Foot, Mae
    Grobbelaar, Melanie
    Whitelaw, Andrew
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2025,
  • [9] Current concepts in antibiotic-resistant Gram-negative bacteria
    Torres, Julian Andres
    Villegas, Maria Virginia
    Quinn, Andjohn P.
    EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2007, 5 (05) : 833 - 843
  • [10] Temporal association between antibiotic use and resistance in Gram-negative bacteria
    Mansy, Wael
    Muzaheed
    Rathod, Sanjay
    ARCHIVES OF PHARMACY PRACTICE, 2020, 11 (02) : 13 - 18