Differential propensity of citrate- and polyethylene glycol-coated silver nanoparticles to bovine hemoglobin

被引:7
|
作者
Zolghadri, Samaneh [1 ]
Saboury, Ali Akbar [2 ]
Atri, Maliheh Sadat [3 ]
Moosavi-Movahedi, A. A. [2 ]
机构
[1] Islamic Azad Univ, Jahrom Branch, Dept Biol, Jahrom, Iran
[2] Univ Tehran, Inst Biochem & Biophys, Tehran 1417614411, Iran
[3] Univ Mazandaran, Fac Basic Sci, Mol & Cell Biol Dept, Babol Sar, Iran
关键词
Citrate-coated silver nanoparticles; hemoglobin; circular dichroism; fluorescence; titration calorimetry; nanoparticle safety; ESCHERICHIA-COLI;
D O I
10.1177/0748233713483193
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Propensity of two different silver nanoparticles (Ag-NPs) to bovine hemoglobin (BHb) was investigated by means of spectroscopic methods. We have combined spectrophotometric and calorimetric methods to show that there is no significant interaction between citrate-coated Ag-NPs and BHb at physiological pH and 20 degrees C. However, our previous results show that polyethylene glycol-coated Ag-NPs strongly bind to Hb and effect on the secondary and tertiary structures of BHb. Thus, a suitable surface coating and modification of surface charge would increase the NPs safety and reduce adverse biological responses.
引用
收藏
页码:721 / 726
页数:6
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