VECTor: A Preclinical Imaging System for Simultaneous Submillimeter SPECT and PET

被引:89
作者
Goorden, Marlies C. [1 ]
van der Have, Frans [1 ,2 ]
Kreuger, Rob [1 ]
Ramakers, Ruud M. [1 ,2 ]
Vastenhouw, Brendan [1 ,2 ]
Burbach, J. Peter H. [3 ]
Booij, Jan [4 ]
Molthoff, Carla F. M. [5 ,6 ]
Beekman, Freek J. [1 ,2 ]
机构
[1] Delft Univ Technol, NL-2629 JB Delft, Netherlands
[2] MILabs, Utrecht, Netherlands
[3] Univ Med Ctr Utrecht, Rudolf Magnus Inst Neurosci, Utrecht, Netherlands
[4] Univ Amsterdam, Acad Med Ctr, Dept Nucl Med, NL-1105 AZ Amsterdam, Netherlands
[5] Vrije Univ Amsterdam, Med Ctr, Dept Nucl Med, Amsterdam, Netherlands
[6] PET Res, Amsterdam, Netherlands
关键词
pinhole; SPECT; PET; small-animal; molecular imaging; neuroimaging; cardiac imaging; ULTRA-HIGH-RESOLUTION; PERFORMANCE EVALUATION; MICROPET SCANNER; PINHOLE; RECONSTRUCTION; DESIGN;
D O I
10.2967/jnumed.112.109538
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Today, PET and SPECT tracers cannot be imaged simultaneously at high resolutions but require 2 separate imaging systems. This paper introduces a Versatile Emission Computed Tomography system (VECTor) for radionuclides that enables simultaneous submillimeter imaging of single-photon and positron-emitting radiolabeled molecules. Methods: gamma-photons produced both by electron-positron annihilation and by single-photon emitters are projected onto the same detectors by means of a novel cylindric high-energy collimator containing 162 narrow pinholes that are grouped in clusters. This collimator is placed in an existing SPECT system (U-SPECT-II) with 3 large-field-of-view gamma-detectors. From the acquired projections, PET and SPECT images are obtained using statistical image reconstruction that corrects for energy-dependent system blurring. Results: For PET tracers, the tomographic resolution obtained with a Jaszczak hot rod phantom was less than 0.8 mm, and 0.5-mm resolution images of SPECT tracers were acquired simultaneously. SPECT images were barely degraded by the simultaneous presence of a PET tracer, even when the activity concentration of the PET tracer exceeded that of the SPECT tracer by up to a factor of 2.5. Furthermore, we simultaneously acquired fully registered 3- and 4-dimensional multiple functional images from living mice that, in the past, could be obtained only sequentially. Conclusion: High-resolution complementary information about tissue function contained in SPECT and PET tracer distributions can now be obtained simultaneously using a fully integrated imaging device. These combined unique capabilities pave the way for new perspectives in imaging the biologic systems of rodents.
引用
收藏
页码:306 / 312
页数:7
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