A new paradigm in dermatopharmacokinetics - Confocal Raman spectroscopy

被引：54

作者：

Mateus, R. ^{[1
]}

Abdalghafor, H. ^{[1
]}

Oliveira, G. ^{[1
]}

Hadgraft, J. ^{[1
]}

Lane, M. E. ^{[1
]}

机构：

[1] UCL Sch Pharm, Dept Pharmaceut, London WC1N 1AX, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2013年 / 444卷 / 1-2期

关键词：

Confocal Raman spectroscopy; Dermatopharmacokinetics; Ibuprofen; Propylene glycol; In vivo; IN-VIVO; HUMAN SKIN; CONCENTRATION PROFILES; PERMEATION; HYDRATION; DELIVERY; RETINOL;

D O I：

10.1016/j.ijpharm.2013.01.036

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Confocal Raman spectroscopy (CRS) is a novel approach which has been used to determine stratum corneum thickness and to profile endogenous skin components. However, the utility of this technique for probing drug disposition in vivo has not been explored to date. In this paper we report the use of CRS to investigate the fate of ibuprofen after application from simple formulations which were previously investigated using the tape-stripping approach. Ibuprofen was prepared in propylene glycol (PG) and propylene glycol/water (PG/H2O) solutions. The formulations were then applied to the volar aspect of the forearm of human volunteers. The results confirmed that ibuprofen distribution profiles in the stratum corneum were comparable to previously published data from tape stripping experiments. We propose CRS as a non-invasive method for dermatopharmacokinetic evaluation of topical pharmaceutical formulations. (C) 2013 Elsevier B. V. All rights reserved.

引用

页码：106 / 108

页数：3

共 15 条

[1]

Caspers PJ, 1998, BIOSPECTROSCOPY, V4, pS31, DOI 10.1002/(SICI)1520-6343(1998)4:5+<S31::AID-BSPY4>3.0.CO

[2]

2-M

[3]

Caspers PJ, 2000, J RAMAN SPECTROSC, V31, P813, DOI 10.1002/1097-4555(200008/09)31:8/9<813::AID-JRS573>3.0.CO

[4]

2-7

[5] Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin [J].

Caspers, PJ ;

Lucassen, GW ;

Puppels, GJ .

BIOPHYSICAL JOURNAL, 2003, 85 (01) :572-580

[6] In vivo confocal Raman microspectroscopy of the skin:: Noninvasive determination of molecular concentration profiles [J].

Caspers, PJ ;

Lucassen, GW ;

Carter, EA ;

Bruining, HA ;

Puppels, GJ .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 116 (03) :434-442

[7] Measuring the effects of topical moisturizers on changes in stratum corneum thickness, water gradients and hydration in vivo [J].

Crowther, J. M. ;

Sieg, A. ;

Blenkiron, P. ;

Marcott, C. ;

Matts, P. J. ;

Kaczvinsky, R. ;

Rawlings, A. V. .

BRITISH JOURNAL OF DERMATOLOGY, 2008, 159 (03) :567-577

[8] Pig ear skin ex vivo as a model for in vivo dermatopharmacokinetic studies in man [J].

Herkenne, Christophe ;

Naik, Aarti ;

Kalia, Yogeshvar N. ;

Hadgraft, Jonathan ;

Guy, Richard H. .

PHARMACEUTICAL RESEARCH, 2006, 23 (08) :1850-1856

[9] Studying the effectiveness of penetration enhancers to deliver retinol through the stratum cornum by in vivo confocal Raman spectroscopy [J].

Melot, Mickael ;

Pudney, Paul D. A. ;

Williamson, Ann-Marie ;

Caspers, Peter J. ;

Van Der Pol, Andre ;

Puppels, Gerwin J. .

JOURNAL OF CONTROLLED RELEASE, 2009, 138 (01) :32-39

[10]

POTTS RO, 1986, J SOC COSMET CHEM, V37, P9

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