A comparison of transcriptional activation by ERα and ERβ

被引：191

作者：

Cowley, SM ^{[1
]}

Parker, MG ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Mol Endocrinol Lab, London WC2A 3PX, England

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1999年 / 69卷 / 1-6期

关键词：

D O I：

10.1016/S0960-0760(99)00055-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have compared the ability of ER alpha and ER beta to stimulate transcription from a number of reporter genes in different cell lines and demonstrate that the activity of AF1 in ER beta is negligible compared with that of ER alpha on ERE based reporters. The activity of AF2 in ER alpha and ER beta is similar and this is likely to reflect their similar ability to bind coactivators. As a consequence, when transcription from a gene depends on both AF1 and AF2 the activity of ER alpha greatly exceeds that of ER beta but when AF1 is not required ER alpha and ER beta have similar transcriptional activities. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：165 / 175

页数：11

共 42 条

[1] MODULATION OF TRANSCRIPTIONAL ACTIVATION BY LIGAND-DEPENDENT PHOSPHORYLATION OF THE HUMAN ESTROGEN RECEPTOR-A/B REGION [J].

ALI, S ;

METZGER, D ;

BORNERT, JM ;

CHAMBON, P .

EMBO JOURNAL, 1993, 12 (03) :1153-1160

[2] CHARACTERIZATION OF THE LIGAND-DEPENDENT TRANSACTIVATION DOMAIN OF THYROID-HORMONE RECEPTOR [J].

BARETTINO, D ;

RUIZ, MDMV ;

STUNNENBERG, HG .

EMBO JOURNAL, 1994, 13 (13) :3039-3049

[3] ROLE OF THE 2 ACTIVATING DOMAINS OF THE ESTROGEN-RECEPTOR IN THE CELL-TYPE AND PROMOTER-CONTEXT DEPENDENT AGONISTIC ACTIVITY OF THE ANTIESTROGEN 4-HYDROXYTAMOXIFEN [J].

BERRY, M ;

METZGER, D ;

CHAMBON, P .

EMBO JOURNAL, 1990, 9 (09) :2811-2818

[4] Molecular basis of agonism and antagonism in the oestrogen receptor [J].

Brzozowski, AM ;

Pike, ACW ;

Dauter, Z ;

Hubbard, RE ;

Bonn, T ;

Engstrom, O ;

Ohman, L ;

Greene, GL ;

Gustafsson, JA ;

Carlquist, M .

NATURE, 1997, 389 (6652) :753-758

[5] Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation [J].

Bunone, G ;

Briand, PA ;

Miksicek, RJ ;

Picard, D .

EMBO JOURNAL, 1996, 15 (09) :2174-2183

[6] INTERACTION OF PROTEINS WITH TRANSCRIPTIONALLY ACTIVE ESTROGEN-RECEPTORS [J].

CAVAILLES, V ;

DAUVOIS, S ;

DANIELIAN, PS ;

PARKER, MG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :10009-10013

[7] NUCLEAR FACTOR RIP140 MODULATES TRANSCRIPTIONAL ACTIVATION BY THE ESTROGEN-RECEPTOR [J].

CAVAILLES, V ;

DAUVOIS, S ;

LHORSET, F ;

LOPEZ, G ;

HOARE, S ;

KUSHNER, PJ ;

PARKER, MG .

EMBO JOURNAL, 1995, 14 (15) :3741-3751

[8] Estrogen receptors alpha and beta form heterodimers on DNA [J].

Cowley, SM ;

Hoare, S ;

Mosselman, S ;

Parker, MG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (32) :19858-19862

[9] IDENTIFICATION OF A CONSERVED REGION REQUIRED FOR HORMONE DEPENDENT TRANSCRIPTIONAL ACTIVATION BY STEROID-HORMONE RECEPTORS [J].

DANIELIAN, PS ;

WHITE, R ;

LEES, JA ;

PARKER, MG .

EMBO JOURNAL, 1992, 11 (03) :1025-1033

[10] ACTIVATION FUNCTION-2 (AF-2) OF RETINOIC ACID RECEPTOR AND 9-CIS RETINOIC ACID RECEPTOR - PRESENCE OF A CONSERVED AUTONOMOUS CONSTITUTIVE ACTIVATING DOMAIN AND INFLUENCE OF THE NATURE OF THE RESPONSE ELEMENT ON AF-2 ACTIVITY [J].

DURAND, B ;

SAUNDERS, M ;

GAUDON, C ;

ROY, B ;

LOSSON, R ;

CHAMBON, P .

EMBO JOURNAL, 1994, 13 (22) :5370-5382

← 1 2 3 4 5 →