Remarkably Efficient Synthesis of 2H-Indazole 1-Oxides and 2H-Indazoles via Tandem Carbon-Carbon Followed by Nitrogen-Nitrogen Bond Formation

被引：41
作者：
Bouillon, Isabelle [1 ]
Zajicek, Jaroslav [1 ]
Pudelova, Nadezda [1 ]
Krchnak, Viktor [1 ]
机构：
[1] Univ Notre Dame, Dept Chem & Biochem, Nieuwland Sci Ctr 251, Notre Dame, IN 46556 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 22期
关键词：
D O I：
10.1021/jo8018895
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Base-catalyzed tandem carbon-carbon followed by nitrogen-nitrogen bond formations quantitatively converted N-alkyl-2-nitro-N-(2-oxo-2-aryl-ethyl)-benzenesulfonamides to 2H-indazoles 1-oxides under mild conditions. Triphenylphosphine or mesyl chloride/triethylamine-mediated deoxygenation afforded 2H-indazoles.
引用
收藏
页码：9027 / 9032
页数：6
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