Diltiazem Hydrochloride Trapping in Poly(methacrylic Acid-Co-Acrylamide) Microparticles: In-Vitro Drug Delivery Studies

被引：5

作者：

Moinuddin, F. ^{[1
]}

Mondal, Subodh ^{[1
]}

Satish, C. S. ^{[1
]}

机构：

[1] PES Coll Pharm, Dept Pharmaceut, Bangalore 560050, Karnataka, India

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2013年 / 62卷 / 09期

关键词：

Diffusion; diltiazem hydrochloride; drug release; microparticles; CONTROLLED-RELEASE; TYROSINE PHOSPHORYLATION; BLEND MICROSPHERES; CYTOTOXICITY; HYDROGEL; CHITOSAN; BEHAVIOR; JUNCTION;

D O I：

10.1080/00914037.2012.734347

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Microparticles based on poly(methacrylic acid-co-acrylamide) crosslinked with N,N'-methylene bisacrylamide were prepared by free radical polymerization using varying amounts of acrylamide (AAm), methacrylic acid (MAA), and N,N'-methylene bisacrylamide (NNMBA). The microparticles were loaded with antihypertensive drug, diltiazem hydrochloride (water-soluble), to investigate their release characteristics. The release behavior in pH 2.0 was much slower than in buffer solution at pH 7.4. The diffusion coefficients ranged from 08.03x106 to 25.40x106cm2 min1 in pH 2.0 buffer and from 02.41x104 to 35.25x104cm2 min1 in pH 7.4 buffer.

引用

页码：469 / 474

页数：6

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