Ordered mesoporous magnesium silicate with uniform nanochannels as a drug delivery system: The effect of calcination temperature on drug delivery rate

被引：48

作者：

Bigham, Ashkan ^{[1
]}

Hassanzadeh-Tabrizi, S. A. ^{[1
]}

Rafienia, Mohammad ^{[2
]}

Salehi, Hossein ^{[3
]}

机构：

[1] Islamic Azad Univ, Najafabad Branch, Dept Mat Engn, Adv Mat Res Ctr, Najafabad, Iran

[2] Isfahan Univ Med Sci, Biosensor Res Ctr, Esfahan, Iran

[3] Isfahan Univ Med Sci, Sch Med, Dept Anat Sci, Esfahan, Iran

来源：

CERAMICS INTERNATIONAL | 2016年 / 42卷 / 15期

关键词：

Ordered mesoporous magnesium silicate; Drug delivery; Ibuprofen; Calcination temperature; REVERSE MICROEMULSION SYNTHESIS; NANOPARTICLES; IBUPROFEN; MCM-41; SURFACTANT; RELEASE; FUNCTIONALIZATION; BIOACTIVITY; COMPOSITE;

D O I：

10.1016/j.ceramint.2016.08.009

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Magnesium silicate nanostructured biomaterials with good bioactivity, biocompatibility, and mechanical properties are promising for applications in various biomedical fields. Herein, ordered mesoporous magnesium silicate (OMMS) was prepared by sol-gel method and the effect of calcination temperature to evaluate its application as ibuprofen (IBU) drug delivery system was investigated. The synthesized powders were calcined at 350, 550, 750 degrees C and characterized by X-ray diffraction (XRD), Fourier trans Mission infrared spectroscopy (FTIR), N-2 adsorption-desorption, and transmission electron microscopy (TEM). All samples demonstrated mesoporous characteristics with high specific surface area ranging from 386 to 504 m(2)/g. It was found that the sample calcined at 350 degrees C showed the slowest drug release rate among all samples, which is due to smaller pore size and the existence of larger amounts of intrawall microporosity. Cytotoxicity of MG63 osteoblast cell line was investigated by MTT assay, indicating no toxicity for IBU- loaded sample calcined at 550 degrees C with a concentration less than 10 mg/ml. This study has revealed that altering the calcination temperature may change the drug delivery behavior of OMMS by influencing textural properties and suggests OMMS as a promising local drug delivery system in bone tissue engineering applications. (C) 2016 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

引用

页码：17185 / 17191

页数：7

共 38 条

[1] Investigation on bioactivity and cytotoxicity of mesoporous nano-composite MCM-48/hydroxyapatite for ibuprofen drug delivery [J].

Aghaei, Hoda ;

Nourbakhsh, Amir Abbas ;

Karbasi, Saeed ;

JavadKalbasi, Roozbeh ;

Rafienia, Mohammad ;

Nourbakhsh, Nosrat ;

Bonakdar, Shahin ;

Mackenzie, Kenneth J. D. .

CERAMICS INTERNATIONAL, 2014, 40 (05) :7355-7362

[2] Bioceramics for drug delivery [J].

Arcos, Daniel ;

Vallet-Regi, Maria .

ACTA MATERIALIA, 2013, 61 (03) :890-911

[3] Confinement and controlled release of bisphosphonates on ordered mesoporous silica-based materials [J].

Balas, Francisco ;

Manzano, Miguel ;

Horcajada, Patricia ;

Vallet-Regi, Maria .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (25) :8116-8117

[4] In vitro evaluation of (S)-ibuprofen toxicity on joint cells and explants of cartilage and synovial membrane [J].

Bedouet, Laurent ;

Pascale, Florentina ;

Bonneau, Michel ;

Wassef, Michel ;

Laurent, Alexandre .

TOXICOLOGY IN VITRO, 2011, 25 (08) :1944-1952

[5] Chitosan enclosed mesoporous silica nanoparticles as drug nano-carriers: Sensitive response to the narrow pH range [J].

Chen, Fang ;

Zhu, Yingchun .

MICROPOROUS AND MESOPOROUS MATERIALS, 2012, 150 (01) :83-89

[6] A new method to produce macropores in calcium phosphate cements [J].

del Real, RP ;

Wolke, JGC ;

Vallet-Regí, M ;

Jansen, JA .

BIOMATERIALS, 2002, 23 (17) :3673-3680

[7] Structure and surface and catalytic properties of Mg-Al basic oxides [J].

Di Cosimo, JI ;

Diez, VK ;

Xu, M ;

Iglesia, E ;

Apesteguia, CR .

JOURNAL OF CATALYSIS, 1998, 178 (02) :499-510

[8] In situ microemulsion synthesis of hydroxyapatite-MgFe2O4 nanocomposite as a magnetic drug delivery system [J].

Foroughi, Firoozeh ;

Hassanzadeh-Tabrizi, S. A. ;

Bigham, Ashkan .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 68 :774-779

[9] Influence of different structured channels of mesoporous silicate on the controlled ibuprofen delivery [J].

Gao, Lin ;

Sun, Jihong ;

Zhang, Li ;

Wang, Jinpeng ;

Ren, Bo .

MATERIALS CHEMISTRY AND PHYSICS, 2012, 135 (2-3) :786-797

[10] Surfactant-assisted sol-gel synthesis of forsterite nanoparticles as a novel drug delivery system [J].

Hassanzadeh-Tabrizi, S. A. ;

Bigham, Ashkan ;

Rafienia, Mohammad .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2016, 58 :737-741

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