Thymoquinone β-Cyclodextrin Nanoparticles System: A Preliminary Study

被引：14

作者：

Cardoso, T. ^{[1
]}

Galhano, C. I. C. ^{[2
,3
]}

Ferreira Marques, M. F. ^{[4
,5
]}

Moreira da Silva, A. ^{[1
,6
]}

机构：

[1] Coimbra Coll Agr, Dept Food Sci & Technol, P-3040316 Coimbra, Portugal

[2] Coimbra Coll Agr, Dept Environm, P-3040316 Coimbra, Portugal

[3] CERNAS Res Unit, P-3040316 Coimbra, Portugal

[4] ISEC IPC, Dept Chem & Biol Engn, P-3031199 Coimbra, Portugal

[5] Univ Coimbra, Dept Phys, CEMUC, P-3004516 Coimbra, Portugal

[6] Univ Coimbra, Res Unit Mol Phys Chem, P-3000535 Coimbra, Portugal

来源：

SPECTROSCOPY-AN INTERNATIONAL JOURNAL | 2012年 / 27卷 / 5-6期

关键词：

beta-cyclodextrin; DSC; FTIR; inclusion compounds; PALS; thymoquinone; INCLUSION COMPLEXES;

D O I：

10.1155/2012/902486

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Thymoquinone is a natural product, the main constituent of Nigella sativa seeds, which exhibits anti-inflammatory and anticancer activities. Among several existing molecules capable of forming an inclusion compound structure, cyclodextrins are applied in the pharmaceutical industry either to increase solubility of hydrophobic molecules or to protect molecules from inactivation or degradation. beta-Cyclodextrin is currently the most common cyclodextrin in pharmaceutical formulations and probably the best studied in humans. In order to study the properties of inclusion compounds based on cyclodextrins and thymoquinone Fourier Transform Infrared (FTIR), Ultraviolet-Visible, Positron Annihilation Lifetime (PAL) Spectroscopies and calorimetric studies by Differential Scanning Calorimetry (DSC) were used. The obtained results indicate the formation of a 1 : 1 inclusion compound between cyclodextrin and thymoquinone. PALS and DSC measurements also provided evidence of the inclusion compound's activity.

引用

页码：329 / 336

页数：8

共 11 条

[1] A review on the use of cyclodextrins in foods [J].

Astray, G. ;

Gonzalez-Barreiro, C. ;

Mejuto, J. C. ;

Rial-Otero, R. ;

Simal-Gandara, J. .

FOOD HYDROCOLLOIDS, 2009, 23 (07) :1631-1640

[2] Inclusion complexes of cyclomaltooligosaccharides (cyclodextrins) with melatonin in solid phase [J].

Bongiorno, D ;

Ceraulo, L ;

Ferrugia, M ;

Filizzola, F ;

Ruggirello, A ;

Liveri, VT .

ARKIVOC, 2005, :118-130

[3]

da Silva A. Moreira, 2009, 9 ENC QUM AL AZ PORT

[4] Cyclodextrins and their uses: a review [J].

Del Valle, EMM .

PROCESS BIOCHEMISTRY, 2004, 39 (09) :1033-1046

[5]

Job P, 1928, ANN CHIM FRANCE, V9, P113

[6] In vitro toxicological properties of thyrnoquinone [J].

Khader, M. ;

Bresgen, N. ;

Eckl, P. M. .

FOOD AND CHEMICAL TOXICOLOGY, 2009, 47 (01) :129-133

[7] Pharmaceutical applications of cyclodextrins .1. Drug solubilization and stabilization [J].

Loftsson, T ;

Brewster, ME .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1996, 85 (10) :1017-1025

[8] Preliminary Positron Lifetime Results on Free Volumes in Cyclodextrins [J].

Marques, M. F. Ferreira ;

da Silva, A. M. G. Moreira ;

Gordo, P. M. ;

Kajcsos, Zs. .

PROGRESS IN POSITRON ANNIHILATION, 2011, 666 :99-+

[9] Inclusion complexes of tretinoin with cyclodextrins [J].

Montassier, P ;

Duchene, D ;

Poelman, MC .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 153 (02) :199-209

[10] RETRACTED: Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential (Retracted article. See vol. 102, pg. 146, 2016) [J].

Ravindran, Jayaraj ;

Nair, Hareesh B. ;

Sung, Bokyung ;

Prasad, Sandeo ;

Tekmal, Rajeshwar R. ;

Aggarwal, Bharat B. .

BIOCHEMICAL PHARMACOLOGY, 2010, 79 (11) :1640-1647

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