Radio-frequency ablation of hepatic metastases: Postprocedural assessment with a US microbubble contrast agent - Early experience

被引:149
作者
Solbiati, L
Goldberg, SN
Ierace, T
Dellanoce, M
Livraghi, T
Gazelle, GS
机构
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, DATA Grp,Dept Radiol, Boston, MA 02114 USA
[2] Osped Gen, Dept Radiol, Busto Arsizio, Italy
[3] Osped Civile, Dept Radiol, Vimercate, MI, Italy
关键词
liver neoplasms; secondary; US; radiofrequency (RF) ablation; ultrasound; (US); contrast media; Doppler studies; power Doppler studies;
D O I
10.1148/radiology.211.3.r99jn06643
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
PURPOSE: To evaluate contrast agent-enhanced ultrasonography (US) in the detection of untreated tumor after radio-frequency (RF)ablation of hepatic metastases. MATERIALS AND METHODS: Twenty patients with solitary colorectal liver metastases underwent percutaneous RF tumor ablation. Pre- and postablation imaging was performed with nonenhanced and enhanced color and power Doppler US and contrast-enhanced helical computed tomography (CT). Initial follow-up CT and US contrast-enhanced helical computed tomography (CT). Initial follow-up CT and US were performed 24 hours after ablation. The findings at US and CT were compared. RESULTS: Nonenhanced US demonstrated intratumoral signal in 15 of 20 metastases before ablation. This signal increased after contrast agent administration. Contrast-enhanced US performed 24 hours after ablation demonstrated residual foci of enhancement in three tumors, whereas no US signals were seen in any tumor on nonenhanced scans. CT demonstrated small (<3-mm) persistent foci of residual enhancement in these three tumors and in three additional lesions that were not seen at US (US sensitivity, 50%; specificity, 100%; diagnostic agreement with CT, 85%). All six patients with evidence of residual tumor underwent;repeat RF ablation. CONCLUSION: Contrast-enhanced US may depict residual tumor after RF application and thereby enable additional directed therapy. The potential reduction in treatment sessions and/or ancillary imaging procedures might increase the ease and practicality of percutaneous ablation;of focal hepatic metastases.
引用
收藏
页码:643 / 649
页数:7
相关论文
共 23 条
  • [1] LIVER-TUMOR ABLATION BY INTERSTITIAL LASER PHOTOCOAGULATION - REVIEW OF EXPERIMENTAL AND CLINICAL-STUDIES
    AMIN, Z
    BOWN, SG
    LEES, WR
    [J]. SEMINARS IN INTERVENTIONAL RADIOLOGY, 1993, 10 (02) : 88 - 100
  • [2] ANZAI Y, 1995, AM J NEURORADIOL, V16, P39
  • [3] Ernst H, 1996, J CLIN ULTRASOUND, V24, P31, DOI 10.1002/(SICI)1097-0096(199601)24:1<31::AID-JCU5>3.0.CO
  • [4] 2-M
  • [5] GALACTOSE-BASED INTRAVENOUS SONOGRAPHIC CONTRAST AGENT - EXPERIMENTAL STUDIES
    GOLDBERG, BB
    LIU, JB
    BURNS, PN
    MERTON, DA
    [J]. JOURNAL OF ULTRASOUND IN MEDICINE, 1993, 12 (08) : 463 - 470
  • [6] Ablation of liver tumors using percutaneous RF therapy
    Goldberg, SN
    Gazelle, GS
    Solbiati, L
    Livraghi, T
    Tanabe, KK
    Hahn, PF
    Mueller, PR
    [J]. AMERICAN JOURNAL OF ROENTGENOLOGY, 1998, 170 (04) : 1023 - 1028
  • [7] Goldberg SN, 1996, ACAD RADIOL, V3, P636
  • [8] Monitoring of radio frequency tissue ablation in an interventional magnetic resonance environment - Preliminary ex vivo and in vivo results
    Goldberg, SN
    Gazelle, GS
    Debatin, JF
    [J]. INVESTIGATIVE RADIOLOGY, 1997, 32 (11) : 671 - 678
  • [9] Use of carbon dioxide microbubble-enhanced sonographic angiography for transcatheter arterial chemoembolization of hepatocellular carcinoma
    Hashimoto, M
    Watanabe, O
    Hirano, Y
    Kato, K
    Watarai, J
    [J]. AMERICAN JOURNAL OF ROENTGENOLOGY, 1997, 169 (05) : 1307 - 1310
  • [10] Microbubble contrast agent for color Doppler US: Effect on breast masses
    Kedar, RP
    Cosgrove, D
    McCready, VR
    Bamber, JC
    Carter, ER
    [J]. RADIOLOGY, 1996, 198 (03) : 679 - 686