Identification and characterization of 2,5-dimethoxy-4-nitro-β-phenethylamine (2C-N) - A new member of 2C-series of designer drug

被引：20

作者：

Zuba, Dariusz ^{[1
]}

Sekula, Karolina ^{[1
]}

Buczek, Agnieszka ^{[1
]}

机构：

[1] Inst Forens Res, PL-31033 Krakow, Poland

来源：

FORENSIC SCIENCE INTERNATIONAL | 2012年 / 222卷 / 1-3期

关键词：

Designer drugs; Legal highs; Identification; Phenethylamines; QUANTITATIVE STRUCTURE-ACTIVITY; HALLUCINOGENIC MESCALINE ANALOGS; CAPILLARY-ELECTROPHORESIS; RAT URINE; DERIVATIVES; SERIES; PHENYLALKYLAMINES; CONNECTIVITY; QSAR;

D O I：

10.1016/j.forsciint.2012.07.006

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The online sale of psychoactive substances, including hallucinogens, is becoming a serious problem in many countries. This paper presents and discusses the mass spectrometric, infrared spectroscopic and nuclear magnetic resonance spectroscopic data of 2,5-dimethoxy-4-nitro-beta-phenethylamine (2C-N), which was identified in a powder sample seized by the authorities in 2011 in Poland. The molecular mass of 2C-N (226.0954 amu) was confirmed in the LC/ESI-QTOFMS experiment. The molecular ion was also observed in the GC-EI/MS spectrum. A characteristic set of ions for the parent substance was found using both chromatographic methods, and when derivatization with trifuluoroacetic anhydride (TFAA) was applied. Two broad dominant bands at 1520 cm(-1) and 1342/1322 cm(-1), observed in the FTIR spectrum of 2C-N, originated from the nitro group. NMR spectroscopy helped unequivocal elucidation of the structure. The applied identification procedure proved to be a powerful tool to determine the structure of a new designer drug. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：298 / 305

页数：8

共 24 条

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