Functional heterogeneity of mesenchymal stem cells from natural niches to culture conditions: implications for further clinical uses

被引:200
作者
Costa, Luis A. [1 ]
Eiro, Noemi [1 ]
Fraile, Maria [1 ]
Gonzalez, Luis O. [1 ,2 ]
Saa, Jorge [1 ]
Garcia-Portabella, Pablo [1 ]
Vega, Belen [1 ]
Schneider, Jose [3 ]
Vizoso, Francisco J. [1 ]
机构
[1] Fdn Hosp Jove, Unidad Invest, Avda Eduardo Castro 161, Gijon 33920, Asturias, Spain
[2] Fdn Hosp Jove, Dept Anat Pathol, Gijon, Spain
[3] Univ Valladolid, Dept Obstet & Gynecol, Valladolid, Spain
关键词
Regenerative medicine; Aging diseases; Diabetes; Lupus; Secretome; Conditioned medium; Extracellular vesicles; Exosomes; ADIPOSE-DERIVED STEM; HUMAN BONE-MARROW; EXPRESSING INTERFERON-BETA; UMBILICAL-CORD BLOOD; FREE LYSATE INHIBIT; LOW-OXYGEN TENSION; STROMAL CELLS; IN-VITRO; PROGENITOR CELLS; GROWTH-FACTOR;
D O I
10.1007/s00018-020-03600-0
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mesenchymal stem cells (MSC) are present in all organs and tissues. Several studies have shown the therapeutic potential effect of MSC or their derived products. However, the functional heterogeneity of MSC constitutes an important barrier for transferring these capabilities to the clinic. MSC heterogeneity depends on their origin (biological niche) or the conditions of potential donors (age, diseases or unknown factors). It is accepted that many culture conditions of the artificial niche to which they are subjected, such as O(2)tension, substrate and extracellular matrix cues, inflammatory stimuli or genetic manipulations can influence their resulting phenotype. Therefore, to attain a more personalized and precise medicine, a correct selection of MSC is mandatory, based on their functional potential, as well as the need to integrate all the existing information to achieve an optimal improvement of MSC features in the artificial niche.
引用
收藏
页码:447 / 467
页数:21
相关论文
共 257 条
  • [91] Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells
    Holzwarth, Christina
    Vaegler, Martin
    Gieseke, Friederike
    Pfister, Stefan M.
    Handgretinger, Rupert
    Kerst, Gunter
    Mueller, Ingo
    [J]. BMC CELL BIOLOGY, 2010, 11
  • [92] Mesenchymal stem cells and cancer: Friends or enemies?
    Hong, In-Sun
    Lee, Hwa-Yong
    Kang, Kyung-Sun
    [J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2014, 768 : 98 - 106
  • [93] Concise Review: Mesenchymal Stromal Cells Anno 2019: Dawn of the Therapeutic Era?
    Hoogduijn, Martin J.
    Lombardo, Eleuterio
    [J]. STEM CELLS TRANSLATIONAL MEDICINE, 2019, 8 (11) : 1126 - 1134
  • [94] Comparative Analysis of Paracrine Factor Expression in Human Adult Mesenchymal Stem Cells Derived from Bone Marrow, Adipose, and Dermal Tissue
    Hsiao, Sarah Tzu-Feng
    Asgari, Azar
    Lokmic, Zerina
    Sinclair, Rodney
    Dusting, Gregory James
    Lim, Shiang Yong
    Dilley, Rodney James
    [J]. STEM CELLS AND DEVELOPMENT, 2012, 21 (12) : 2189 - 2203
  • [95] Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis
    Hu, Xinyang
    Yu, Shan Ping
    Fraser, Jamie L.
    Lu, Zhongyang
    Ogle, Molly E.
    Wang, Jian-An
    Wei, Ling
    [J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2008, 135 (04) : 799 - 808
  • [96] Hypoxia promotes proliferation and osteogenic differentiation potentials of human mesenchymal stem cells
    Hung, Shun-Pei
    Ho, Jennifer H.
    Shih, Yu-Ru V.
    Lo, Ting
    Lee, Oscar K.
    [J]. JOURNAL OF ORTHOPAEDIC RESEARCH, 2012, 30 (02) : 260 - 266
  • [97] Emerging models and paradigms for stem cell ageing
    Jones, D. Leanne
    Rando, Thomas A.
    [J]. NATURE CELL BIOLOGY, 2011, 13 (05) : 506 - 512
  • [98] Human Wharton's Jelly Stem Cell (hWJS']JSC) Extracts Inhibit Ovarian Cancer Cell Lines OVCAR3 and SKOV3 in vitro by Inducing Cell Cycle Arrest and Apoptosis
    Kalamegam, Gauthaman
    Sait, Khalid Hussein Wall
    Ahmed, Farid
    Kadam, Roaa
    Pushparaj, Peter Natesan
    Anfinan, Nisreen
    Rasoo, Mahmood
    Jamal, Mohammad Sarwar
    Abu-Elmagd, Muhammed
    Al-Qahtani, Mohammed
    [J]. FRONTIERS IN ONCOLOGY, 2018, 8
  • [99] Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    Karnoub, Antoine E.
    Dash, Ajeeta B.
    Vo, Annie P.
    Sullivan, Andrew
    Brooks, Mary W.
    Bell, George W.
    Richardson, Andrea L.
    Polyak, Kornelia
    Tubo, Ross
    Weinberg, Robert A.
    [J]. NATURE, 2007, 449 (7162) : 557 - U4
  • [100] Mesenchymal stem cells regulate angiogenesis according to their mechanical environment
    Kasper, Grit
    Dankert, Niels
    Tuischer, Jens
    Hoeft, Moritz
    Gaber, Timo
    Glaeser, Juliane D.
    Zander, Desiree
    Tschirschmann, Miriam
    Thompson, Mark
    Matziolis, Georg
    Duda, Georg N.
    [J]. STEM CELLS, 2007, 25 (04) : 903 - 910