ACTIVATION OF THE MITOCHONDRIAL CLPP PROTEASE IS SYNTHETICALLY LETHAL WITH HDAC1/2 INHIBITION IN GLIOBLASTOMA MODEL SYSTEMS

被引:0
作者
Schiffgens, Salveena [1 ]
Trang Nguyen [1 ]
Shu, Chang [1 ]
Elena, Bianchetti [1 ]
Torrini, Consuelo [1 ]
Karpel-Massler, Georg [2 ]
Siegelin, Markus [1 ]
机构
[1] Columbia Univ, Med Ctr, New York, NY USA
[2] Ulm Univ, Med Ctr, Ulm, Germany
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
EXTH-50
引用
收藏
页码:98 / 98
页数:1
相关论文
共 50 条
[31]   Hydroxytyrosol ameliorates stress-induced liver injury through activating autophagy via HDAC1/2 inhibition [J].
Fan, Li ;
Zhao, Lijuan ;
Zhu, Yangbo ;
Li, Lin ;
Yang, Xueping ;
Ma, Ping ;
Liu, Jian ;
Zhao, Qingwei ;
Li, Xiaobo .
FOOD & FUNCTION, 2024, 15 (09) :5103-5117
[32]   EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma-Induced Epigenetic Suppression of Osteoblast Differentiation [J].
Adamik, Juraj ;
Jin, Shunqian ;
Sun, Quanhong ;
Zhang, Peng ;
Weiss, Kurt R. ;
Anderson, Judith L. ;
Silbermann, Rebecca ;
Roodman, G. David ;
Galson, Deborah L. .
MOLECULAR CANCER RESEARCH, 2017, 15 (04) :405-417
[33]   Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury [J].
Pryce, Kerri D. ;
Serafini, Randal A. ;
Ramakrishnan, Aarthi ;
Nicolais, Andrew ;
Giosan, Ilinca M. ;
Polizu, Claire ;
Torres-Berrio, Angelica ;
Vuppala, Sreeya ;
Kronman, Hope ;
Ruiz, Anne ;
Gaspari, Sevasti ;
Pena, Catherine J. ;
Sakloth, Farhana ;
Mitsi, Vasiliki ;
van Duzer, John ;
Mazitschek, Ralph ;
Jarpe, Matthew ;
Shen, Li ;
Nestler, Eric J. ;
Zachariou, Venetia .
NATURE NEUROSCIENCE, 2023, 26 (07) :1229-+
[34]   Oxycodone withdrawal induces HDAC1/HDAC2-dependent transcriptional maladaptations in the reward pathway in a mouse model of peripheral nerve injury [J].
Kerri D. Pryce ;
Randal A. Serafini ;
Aarthi Ramakrishnan ;
Andrew Nicolais ;
Ilinca M. Giosan ;
Claire Polizu ;
Angélica Torres-Berrío ;
Sreeya Vuppala ;
Hope Kronman ;
Anne Ruiz ;
Sevasti Gaspari ;
Catherine J. Peña ;
Farhana Sakloth ;
Vasiliki Mitsi ;
John van Duzer ;
Ralph Mazitschek ;
Matthew Jarpe ;
Li Shen ;
Eric J. Nestler ;
Venetia Zachariou .
Nature Neuroscience, 2023, 26 :1229-1244
[35]   TOPK Promotes Microglia/Macrophage Polarization towards M2 Phenotype via Inhibition of HDAC1 and HDAC2 Activity after Transient Cerebral Ischemia [J].
Han, Ziping ;
Zhao, Haiping ;
Tao, Zhen ;
Wang, Rongliang ;
Fan, Zhibin ;
Luo, Yumin ;
Luo, Yinghao ;
Ji, Xunming .
AGING AND DISEASE, 2018, 9 (02) :235-248
[36]   The transcription repressor, ZEB1, cooperates with CtBP2 and HDAC1 to suppress IL-2 gene activation in T cells [J].
Wang, Jun ;
Lee, Seungsoo ;
Teh, Charis En-Yi ;
Bunting, Karen ;
Ma, Lina ;
Shannon, M. Frances .
INTERNATIONAL IMMUNOLOGY, 2009, 21 (03) :227-235
[37]   Inhibition of HDAC1 and 3 in the Presence of Systemic Inflammation Reduces Retinal Degeneration in a Model of Dry Age-Related Macular Degeneration [J].
Husain, Shahid ;
Obert, Elisabeth ;
Singh, Sudha ;
Schnabolk, Gloriane .
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 2024, 40 (06) :397-406
[38]   Combined inhibition of PI3K and HDAC1/2 as a novel treatment strategy for RAS/RAF wildtype colorectal cancer in a patient derived organoid model [J].
DeZeeuw, Alyssa K. ;
DeStefanis, Rebecca A. ;
Payne, Susan N. ;
Olson, Autumn M. ;
Pasch, Cheri A. ;
Clipson, Linda ;
Deming, Dustin A. .
CANCER RESEARCH, 2022, 82 (12)
[39]   Combinatorial In Silico Strategy towards Identifying Potential Hotspots during Inhibition of Structurally Identical HDAC1 and HDAC2 Enzymes for Effective Chemotherapy against Neurological Disorders [J].
Ganai, Shabir Ahmad ;
Abdullah, Ehsaan ;
Rashid, Romana ;
Altaf, Mohammad .
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2017, 10
[40]   Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2 [J].
Lin, Yi-Chu ;
Lin, Jung-Hsin ;
Chou, Chia-Wei ;
Chang, Yu-Fan ;
Yeh, Shu-Hao ;
Chen, Ching-Chow .
CANCER RESEARCH, 2008, 68 (07) :2375-2383