ACTIVATION OF THE MITOCHONDRIAL CLPP PROTEASE IS SYNTHETICALLY LETHAL WITH HDAC1/2 INHIBITION IN GLIOBLASTOMA MODEL SYSTEMS

被引：0
|
作者：
Schiffgens, Salveena [1 ]
Trang Nguyen [1 ]
Shu, Chang [1 ]
Elena, Bianchetti [1 ]
Torrini, Consuelo [1 ]
Karpel-Massler, Georg [2 ]
Siegelin, Markus [1 ]
机构：
[1] Columbia Univ, Med Ctr, New York, NY USA
[2] Ulm Univ, Med Ctr, Ulm, Germany
来源：
NEURO-ONCOLOGY | 2020年 / 22卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
EXTH-50
引用
收藏
页码：98 / 98
页数：1
相关论文
共 50 条
  • [1] Induction of Synthetic Lethality by Activation of Mitochondrial ClpP and Inhibition of HDAC1/2 in Glioblastoma
    Nguyen, Trang T. T.
    Shang, Enyuan
    Schiffgens, Salveena
    Torrini, Consuelo
    Shu, Chang
    Akman, Hasan Orhan
    Prabhu, Varun V.
    Allen, Joshua E.
    Westhoff, Mike-Andrew
    Karpel-Massler, Georg
    Siegelin, Markus D.
    CLINICAL CANCER RESEARCH, 2022, 28 (09) : 1881 - 1895
  • [2] INDUCTION OF SYNTHETIC LETHALITY BY ACTIVATION OF MITOCHONDRIAL CLPP AND INHIBITION OF HDAC1/2 IN GLIOBLASTOMA
    Nguyen, Trang
    Shang, Enyuan
    Schiffgens, Salveena
    Torrini, Consuelo
    Bianchetti, Elena
    Shu, Chang
    Akman, Hasan Orhan
    Prabhu, Varun
    Allen, Joshua
    Westhoff, Mike-Andrew
    Karpel-Massler, Georg
    Siegelin, Markus D.
    NEURO-ONCOLOGY, 2021, 23 : 201 - 201
  • [3] Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems
    Nguyen, Trang T. T.
    Zhang, Yiru
    Shang, Enyuan
    Shu, Chang
    Quinzii, Catarina M.
    Westhoff, Mike-Andrew
    Karpel-Massler, Georg
    Siegelin, Markus D.
    CELLS, 2020, 9 (07) : 1 - 18
  • [4] Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems
    Enyuan Shang
    Yiru Zhang
    Chang Shu
    Chiaki Tsuge Ishida
    Elena Bianchetti
    Mike-Andrew Westhoff
    Georg Karpel-Massler
    Markus D. Siegelin
    Scientific Reports, 8
  • [5] Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems
    Shang, Enyuan
    Zhang, Yiru
    Shu, Chang
    Ishida, Chiaki Tsuge
    Bianchetti, Elena
    Westhoff, Mike-Andrew
    Karpel-Massler, Georg
    Siegelin, Markus D.
    SCIENTIFIC REPORTS, 2018, 8
  • [6] Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma
    Shang, Enyuan
    Nguyen, Trang T. T.
    Shu, Chang
    Westhoff, Mike-Andrew
    Karpel-Massler, Georg
    Siegelin, Markus D.
    CANCERS, 2020, 12 (08) : 1 - 21
  • [7] INHIBITION OF SREBP-1 IS SYNTHETICALLY LETHAL WITH BCL-XL/BCL-2 INHIBITION IN GLIOBLASTOMA IN VITRO
    Tosin, Davide
    Schlotter, Dominik
    Hajosch, Annika
    Hlavac, Michal
    Westhoff, Mike-Andrew
    Siegelin, Markus
    Wirtz, Christian Rainer
    Karpel-Massler, Georg
    NEURO-ONCOLOGY, 2022, 24 : 220 - 220
  • [8] Increased activation of HDAC1/2/6 and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma
    Yang, Wen-Bin
    Hsu, Che-Chia
    Hsu, Tsung-, I
    Liou, Jing-Ping
    Chang, Kwang-Yu
    Chen, Pin-Yuan
    Liu, Jr-Jiun
    Yang, Shung-Tai
    Wang, Jia-Yi
    Yeh, Shiu-Hwa
    Chen, Ruei-Ming
    Chang, Wen-Chang
    Chuang, Jian-Ying
    NEURO-ONCOLOGY, 2020, 22 (10) : 1439 - 1451
  • [9] Increased activation of HDAC1, 2, and 6, and Sp1 underlies therapeutic resistance and tumor growth in glioblastoma
    Chuang, Jian-Ying
    Yang, Wen-Bin
    Hsu, Che-Chia
    FASEB JOURNAL, 2020, 34
  • [10] MTORC1/2 and HDAC1/2 inhibition promote tumor response through inhibition of MYC
    DeStefanis, Rebecca A.
    Olson, Autumn M.
    DeZeeuw, Alyssa K.
    Payne, Susan N.
    Pasch, Cheri A.
    Clipson, Linda
    Deming, Dustin A.
    CANCER RESEARCH, 2022, 82 (12)
12345