Is Sonothrombolysis an Effective Stroke Treatment?

被引：13
作者：
Mijajlovic, Milija D. [1 ,2 ]
Pavlovic, Aleksandra M.
Covickovic-Sternic, Nadezda
机构：
[1] Univ Belgrade, Clin Ctr Serbia, Neurol Clin, Belgrade 11000, Serbia
[2] Univ Belgrade, Sch Med, Belgrade 11000, Serbia
来源：
JOURNAL OF ULTRASOUND IN MEDICINE | 2013年 / 32卷 / 07期
关键词：
acute ischemic stroke; efficacy; mechanisms of action; safety; sonothrombolysis; ACUTE ISCHEMIC-STROKE; TISSUE-PLASMINOGEN ACTIVATOR; ULTRASOUND-ENHANCED THROMBOLYSIS; IN-VITRO; SYSTEMIC THROMBOLYSIS; LYSIS; TRIAL; RECANALIZATION; FREQUENCY; OCCLUSION;
D O I：
10.7863/ultra.32.7.1117
中图分类号：
O42 [声学];
学科分类号：
070206 ; 082403 ;
摘要：
New therapeutic strategies under development aim to improve recanalization rates and clinical outcomes after ischemic stroke. One such approach is ultrasound (US)enhanced thrombolysis, or sonothrombolysis, which can improve thrombolytic drug actions and even intrinsic fibrinolysis. Although the mechanisms are not fully understood, it is postulated that thrombolysis enhancement is related to nonthermal mechanical effects of US. Recent results indicate that US with or without microbubbles maybe effective in clot lysis of ischemic stroke even without additional thrombolytic drugs. Sonothrombolysis is a promising tool for treating acute ischemic stroke, but its efficacy, safety, and technical details have not been elucidated and proved yet in stroke treatment.
引用
收藏
页码：1117 / 1123
页数：7
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