Operator-independent quantitative chest computed tomography versus standard assessment of interstitial lung disease related to systemic sclerosis: A multi-centric study

被引：21

作者：

Ariani, Alarico ^{[1
]}

Silva, Mario ^{[2
]}

Bravi, Elena ^{[3
]}

Saracco, Marta ^{[4
]}

Parisi, Simone ^{[5
]}

De Gennaro, Fabio ^{[6
]}

Lumetti, Federica ^{[1
]}

Idolazzi, Luca ^{[7
]}

Seletti, Valeria ^{[2
]}

Caramaschi, Paola ^{[7
]}

Benini, Camilla ^{[7
]}

Bodini, Flavio Cesare ^{[8
]}

Scire, Carlo Alberto ^{[9
]}

Lucchini, Gianluca ^{[1
]}

Santilli, Daniele ^{[1
]}

Mozzani, Flavio ^{[1
]}

Imberti, Davide ^{[3
]}

Arrigoni, Eugenio ^{[3
]}

Delsante, Giovanni ^{[1
]}

Pellerito, Raffaele ^{[4
]}

Fusaro, Enrico ^{[5
]}

Sverzellati, Nicola ^{[2
]}

机构：

[1] Azienda Osped Univ Parma, Internal Med & Rheutnatol Unit, Dept Med, I-43100 Parma, Italy

[2] Univ Parma, Sect Radiol, Dept Clin Sci, I-43100 Parma, Italy

[3] Osped G Da Saliceto, Internal Med & Rheumatol Unit, Dept Med, Piacenza, Italy

[4] Osped Mauriziano Umberto I Torino, Rheumatol Unit, Turin, Italy

[5] Azienda Osped Citta Salute & Sci Torino, Dept Rheumatol, Turin, Italy

[6] Azienda Osped Ist Ospitalieri Cremona, Rheumatol Unit, Cremona, Italy

[7] Univ Verona, Dept Med, Rheumatol Sect, Policlin Borg Roma, I-37100 Verona, Italy

[8] Osped G Da Saliceto, Radiol Unit, Piacenza, Italy

[9] Italian Soc Rheumatol, Epidemiol Unit, Milan, Italy

来源：

MODERN RHEUMATOLOGY | 2015年 / 25卷 / 05期

关键词：

CT indexes; CT quantitative assessment; Interstitial lung disease; OsiriX; Systemic sclerosis; HIGH-RESOLUTION CT; OPEN-SOURCE SOFTWARE; PULMONARY-FIBROSIS; DIFFUSING-CAPACITY; CARBON-MONOXIDE; INDEXES; MORTALITY; QUANTIFICATION; DIAGNOSIS; SEVERITY;

D O I：

10.3109/14397595.2015.1016200

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose. Interstitial lung disease (ILD) related to systemic sclerosis (SSc) is assessed with pulmonary functional tests (PFTs) and semi-quantitative scores based on extent of ILD detectable on chest computed tomography (CT). CT quantitative indexes (QCTIs) are promising tools to assess extent of ILD. This study's aim is to evaluate the validity of QCTI compared with that of chest CT standard evaluation and PFTs. Moreover, QCTI differences between patients' subgroups according to prognostic stratifications were investigated. Methods. ILD-SSc of patients from six rheumatological clinics was routinely assessed with chest CT and PFTs. Patients were clustered according to prognosis based on functional and/or radiological examinations. Finally, chest CTs were processed with OsiriX in order to obtain QCTI. Results. Two hundred fifty-seven SSc patients were enrolled. QCTI correlation between extent of ILD and PFTs range from - 0.60 to 0.58 and from - 0.54 to 0.52, respectively. The majority of QCTI have a different distribution in patients' subgroups based on prognosis. Most of QCTI discriminate patients with an ILD severity leading to a poor prognosis. Conclusions. QCTI assessment of ILD-SSc is comparable to the evaluation based on chest CT and/or PFTs. QCTI values corresponding to severe ILD were identified. QCTIs are excellent candidates for a new and more reliable SSc-ILD assessment.

引用

页码：724 / 730

页数：7

共 42 条

[1]

Ariani A, 2014, J BIOL REG HOMEOS AG, V28, P507

[2] Utility of an open-source DICOM viewer software (OsiriX) to assess pulmonary fibrosis in systemic sclerosis: preliminary results [J].

Ariani, Alarico ;

Carotti, Marina ;

Gutierrez, Marwin ;

Bichisecchi, Elisabetta ;

Grassi, Walter ;

Giuseppetti, Gian Marco ;

Salaffi, Fausto .

RHEUMATOLOGY INTERNATIONAL, 2014, 34 (04) :511-516

[3] HRCT and scleroderma: semiquantitative evaluation of lung damage and functional abnormalities [J].

Bellia, M. ;

Cannizzaro, F. ;

Scichilone, N. ;

Riili, M. ;

Triolo, G. ;

Midiri, M. ;

Lagalla, R. .

RADIOLOGIA MEDICA, 2009, 114 (02) :190-203

[4] Quantitative CT indexes in idiopathic pulmonary fibrosis: Relationship with physiologic impairment [J].

Best, AC ;

Lynch, AM ;

Bozic, CM ;

Miller, D ;

Grunwald, GK ;

Lynch, DA .

RADIOLOGY, 2003, 228 (02) :407-414

[5] Lung CT densitometry in systemic sclerosis - Correlation with lung fuction, exercise testing, and quality of life [J].

Camiciottoli, Gianna ;

Orlandi, Ilaria ;

Bartolucci, Maurizio ;

Meoni, Eleonora ;

Nacci, Francesca ;

Diciotti, Stefano ;

Barcaroli, Chiara ;

Conforti, Maria Letizia ;

Pistolesi, Massimo ;

Matucci-Cerinic, Marco ;

Mascalchi, Mario .

CHEST, 2007, 131 (03) :672-681

[6] Clinical prediction of 5-year survival in systemic sclerosis: validation of a simple prognostic model in EUSTAR centres [J].

Fransen, J. ;

Popa-Diaconu, D. ;

Hesselstrand, R. ;

Carreira, P. ;

Valentini, G. ;

Beretta, L. ;

Airo, P. ;

Inanc, M. ;

Ullman, S. ;

Balbir-Gurman, A. ;

Sierakowski, S. ;

Allanore, Y. ;

Czirjak, L. ;

Riccieri, V. ;

Giacomelli, R. ;

Gabrielli, A. ;

Riemekasten, G. ;

Matucci-Cerinic, M. ;

Farge, D. ;

Hunzelmann, N. ;

Van den Hoogen, F. H. J. ;

Vonk, M. C. .

ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (10) :1788-1792

[7] Interstitial lung disease in systemic sclerosis - A simple staging system [J].

Goh, Nicole S. L. ;

Desai, Sujai R. ;

Veeraraghavan, Srihari ;

Hansell, David M. ;

Copley, Susan J. ;

Maher, Toby M. ;

Corte, Tarnera J. ;

Sander, Clare R. ;

Ratoff, Jonathan ;

Devaraj, Anand ;

Bozovic, Gracijela ;

Denton, Christopher P. ;

Black, Carol M. ;

du Bois, Roland M. ;

Wells, Athol U. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 177 (11) :1248-1254

[8] Quantitative CT of the lung [J].

Goldin, JG .

RADIOLOGIC CLINICS OF NORTH AMERICA, 2002, 40 (01) :145-+

[9] Treatment of Scleroderma-Interstitial Lung Disease With Cyclophosphamide Is Associated With Less Progressive Fibrosis on Serial Thoracic High-Resolution CT Scan Than Placebo Findings From the Scleroderma Lung Study [J].

Goldin, Jonathan ;

Elashoff, Robert ;

Kim, Hyun J. ;

Yan, Xaiohong ;

Lynch, David ;

Strollo, Diane ;

Roth, Michael D. ;

Clements, Philip ;

Furst, Daniel E. ;

Khanna, Dinesh ;

Vasunilashorn, Srainnapha ;

Li, Gang ;

Tashkin, Donald P. .

CHEST, 2009, 136 (05) :1333-1340

[10] Comparison of different measures of diffusing capacity for carbon monoxide (DLCO) in systemic sclerosis [J].

Hudson, Marie ;

Assayag, Deborah ;

Caron, Melissa ;

Fox, Benjamin D. ;

Hirsch, Andrew ;

Steele, Russell ;

Gaudreau-Taillefer, Rebecca ;

Tatibouet, Solene ;

Rudski, Lawrence ;

Baron, Murray .

CLINICAL RHEUMATOLOGY, 2013, 32 (10) :1467-1474

← 1 2 3 4 5 →