Phase 3 Trial of Acalabrutinib in Combination with Venetoclax, With and Without Obinutuzumab Versus Chemoimmunotherapy for Previously Untreated Chronic Lymphocytic Leukemia (CLL)

被引:0
|
作者
Brown, Jennifer R. [1 ]
Eichhorst, Barbara [2 ]
Ghia, Paolo [3 ,4 ]
Kater, A. P. [5 ]
Li, Jianyong [6 ]
Khurana, Sudha [7 ]
Elhamy, Mostafa [7 ]
Wang, Min Hui [7 ]
Seymour, John F. [8 ,9 ]
机构
[1] Dana Farber Canc Inst, Boston, MA 02115 USA
[2] Univ Hosp Cologne, Cologne, Germany
[3] Univ Vita Salute Raffaele, Milan, Italy
[4] IRCCS Osped San Raffaele, Milan, Italy
[5] Amsterdam UMC, Amsterdam, Netherlands
[6] Nanjing Med Univ, Affiliated Hosp 1, Jiansu Sheng, Peoples R China
[7] Acerta Pharma, San Francisco, CA USA
[8] Peter MacCallum Canc Ctr, Melbourne, Vic, Australia
[9] Royal Melbourne Hosp, Melbourne, Vic, Australia
关键词
CLL; chronic lymphocytic leukemia; acalabrutinib; Bruton tyrosine kinase inhibitor; combination therapy;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
CLL-092
引用
收藏
页码:S221 / S222
页数:2
相关论文
共 50 条
  • [21] Acalabrutinib with Obinutuzumab in Treatment-Naive (TN) and Relapsed/Refractory (R/R) Patients with Chronic Lymphocytic Leukemia (CLL): 3-Year Follow-Up
    Woyach, Jennifer A.
    Rogers, Kerry A.
    Bhat, Seema
    Blachly, James
    Jianfar, Mojgan
    Frigault, Melanie M.
    Hamdy, Ahmed
    Izumi, Raquel
    Munugalavadla, Veerendra
    Quah, Cheng
    Wang, Min Hui
    Byrd, John C.
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 : S281 - S281
  • [22] Safety and efficacy of acalabrutinib and obinutuzumab in treatment-naive chronic lymphocytic leukemia: a Japanese phase 1 study
    Takizawa, Jun
    Teshima, Takanori
    Ennishi, Daisuke
    Ichikawa, Satoshi
    Suzuki, Ritsuro
    Kojima, Akira
    Takahashi, Yusuke
    Hayashi, Nobuya
    Kawasumi, Hisashi
    Murayama, Kosho
    Cheung, Patricia
    Kawata, Toshio
    Izutsu, Koji
    LEUKEMIA & LYMPHOMA, 2024, 65 (11) : 1586 - 1594
  • [23] Phase II Study of Combination Obinutuzumab, Ibrutinib, and Venetoclax in Treatment-Naive and Relapsed or Refractory Chronic Lymphocytic Leukemia
    Rogers, Kerry A.
    Huang, Ying
    Ruppert, Amy S.
    Abruzzo, Lynne V.
    Andersen, Barbara L.
    Awan, Farrukh T.
    Bhat, Seema A.
    Dean, Allison
    Lucas, Margaret
    Banks, Christin
    Grantier, Cara
    Heerema, Nyla A.
    Lozanski, Gerard
    Maddocks, Kami J.
    Valentine, Thomas R.
    Weiss, David M.
    Jones, Jeffrey A.
    Woyach, Jennifer A.
    Byrd, John C.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (31) : 3626 - +
  • [24] A phase II Japanese trial of fludarabine, cyclophosphamide and rituximab for previously untreated chronic lymphocytic leukemia
    Izutsu, Koji
    Kinoshita, Tomohiro
    Takizawa, Jun
    Fukuhara, Suguru
    Yamamoto, Go
    Ohashi, Yasuo
    Suzumiya, Junji
    Tobinai, Kensei
    JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2021, 51 (03) : 408 - 415
  • [25] Ibrutinib followed by ofatumumab consolidation in previously untreated patients with chronic lymphocytic leukemia (CLL): GELLC-7 trial from the Spanish group of CLL (GELLC)
    Abrisqueta, Pau
    Gonzalez-Barca, Eva
    Ferra, Christelle
    Rios-Herranz, Eduardo
    de la Mata, Margarita Fernandez
    Delgado, Julio
    Andreu, Rafael
    Hernandez-Rivas, Jose angel
    Terol, Maria Jose
    Navarro, Almudena
    Vidriales, M. Belen
    Baltasar, Patricia
    De la Serna, Javier
    Ramirez, Angel
    Ballester, Carmen
    Moreno, Carol
    Garcia-Marco, Jose Antonio
    Cordoba, Raul
    Yanez, Lucrecia
    Casado, Luis Felipe
    Gonzalez, Marcos
    Bosch, Francesc
    ECLINICALMEDICINE, 2024, 73
  • [26] Safety of obinutuzumab alone or combined with chemotherapy for previously untreated or relapsed/refractory chronic lymphocytic leukemia in the phase IIIb GREEN study
    Leblond, Veronique
    Aktan, Melih
    Ferra Coll, Christelle M.
    Dartigeas, Caroline
    Kisro, Jens
    Montillo, Marco
    Raposo, Joao
    Merot, Jean-Louis
    Robson, Susan
    Gresko, Ekaterina
    Bosch, Francesc
    Stilgenbauer, Stephan
    Foa, Robin
    HAEMATOLOGICA, 2018, 103 (11) : 1889 - 1898
  • [27] Obinutuzumab: A Novel Anti-CD20 Monoclonal Antibody for Previously Untreated Chronic Lymphocytic Leukemia
    Shah, Arpita
    ANNALS OF PHARMACOTHERAPY, 2014, 48 (10) : 1356 - 1361
  • [28] 2-CHLORODEOXYADENOSINE (CDA) FOR PATIENTS WITH PREVIOUSLY UNTREATED CHRONIC LYMPHOCYTIC-LEUKEMIA (CLL)
    DELANNOY, A
    MARTIAT, P
    GALA, JL
    DENEYS, V
    FERRANT, A
    BOSLY, A
    SCHEIFF, JM
    MICHAUX, JL
    LEUKEMIA, 1995, 9 (07) : 1130 - 1135
  • [29] Phase 2 Study of Acalabrutinib in Ibrutinib-Intolerant Patients with Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia (CLL)
    Rogers, Kerry A.
    Thompson, Philip A.
    Allan, John N.
    Coleman, Morton
    Sharman, Jeff P.
    Cheson, Bruce D.
    Izumi, Raquel
    Frigault, Melanie M.
    Quah, Cheng
    Raman, Rakesh K.
    Wang, Min Hui
    Kipps, Thomas J.
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2019, 19 : S282 - S283
  • [30] Zanubrutinib, obinutuzumab, and venetoclax with minimal residual disease-driven discontinuation in previously untreated patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: a multicentre, single-arm, phase 2 trial
    Soumerai, Jacob D.
    Mato, Anthony R.
    Dogan, Ahmet
    Seshan, Venkatraman E.
    Joffe, Erel
    Flaherty, Kelsey
    Carter, Jason
    Hochberg, Ephraim
    Barnes, Jeffrey A.
    Hamilton, Audrey M.
    Abramson, Jeremy S.
    Batlevi, Connie L.
    Matasar, Matthew J.
    Noy, Ariela
    Owens, Colette N.
    Palomba, M. Lia
    Kumar, Anita
    Takvorian, Tak
    Ni, Ai
    Choma, Morgan
    Friedman, Chaya
    Chadha, Puja
    Simkins, Elizabeth
    Ruiters, Jade
    Sechio, Sidney
    Portman, Daneal
    Ramos, Lauren
    Nolet, Natascha
    Mahajan, Neena
    Martignetti, Rosalba
    Mi, Joanna
    Scorsune, Krista
    Lynch, Julia
    McGree, Brianne
    Hughes, Stephanie
    Grieve, Clare
    Roeker, Lindsey E.
    Thompson, Meghan
    Johnson, P. Connor
    Roshal, Mikhail
    Huang, Jane
    Biondo, Juliana
    Wu, Qun
    Jacob, Allison
    Abdel-Wahab, Omar
    Zelenetz, Andrew D.
    LANCET HAEMATOLOGY, 2021, 8 (12): : E879 - E890