Short- and long-term immune responses of CD-1 outbred mice to the scrub typhus DNA vaccine candidate: p47Kp

被引：10

作者：

Xu, Guang

Chattopadhyay, Suchismita

Jiang, Ju

Chan, Teik-Chye

Chao, Chien-Chung

Ching, Wei-Mei

Richards, Allen L.

机构：

[1] USN, Med Res Ctr, Rickettsial Dis Dept, Silver Spring, MD 20910 USA

[2] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA

来源：

RICKETTSIOSES: FROM GENOME TO PROTEOME, PATHOBIOLOGY, AND RICKETTSIAE AS AN INTERNATIONAL THREAT | 2005年 / 1063卷

关键词：

CD-1; mice; immunization; p47Kp; scrub typhus; vaccine;

D O I：

10.1196/annals.1355.043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Orientia tsutsugamushi is an obligate intracellular bacterium that is the causative agent of scrub typhus. To develop an effective vaccine to prevent or ameliorate scrub typhus, knowledge of the protective immune response to O. tsutsugamushi needs to be ascertained. Our laboratory has demonstrated that the DNA vaccine vector pVR1012 carrying the O. tsutsugamushi Karp strain 47-kDa protein gene (p47Kp) consistently provides outbred mice protection against homologous challenge.

引用

页码：266 / 269

页数：4