Patients with hepatitis C infection and normal liver function: an evaluation of cognitive function

被引:24
作者
Abrantes, Jefferson [1 ]
Torres, Daniel Simplicio [1 ]
Brandao de Mello, Carlos Eduardo [2 ]
机构
[1] Univ Fed Estado Rio de Janeiro, Fed Univ State Rio de Janeiro, Dept Neurol, Rio De Janeiro, RJ, Brazil
[2] Univ Fed Estado Rio de Janeiro, Fed Univ State Rio de Janeiro, Dept Gastroenterol, Rio De Janeiro, RJ, Brazil
关键词
NEUROLOGY; INFECTIOUS DISEASES; EXTRAHEPATIC MANIFESTATIONS; NEUROPSYCHOLOGICAL BATTERY; VIRUS-INFECTION; DISEASE; DEPRESSION;
D O I
10.1136/postgradmedj-2012-131185
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of the study Hepatitis C virus (HCV) is associated with neuropsychiatric complaints. Previous studies have associated cognitive alterations with HCV infection but have often included confounding factors in their samples. This study compares the cognitive performance between patients with HCV infection (HCV patients) and a control group while excluding other factors that may cause cognitive impairment. Study design This cross-sectional study was conducted from March 2010 through June 2011. HCV infected patients and healthy individuals between the ages of 18 and 80years were considered eligible. The exclusion criteria included well established causes of cognitive impairment such as depression and cirrhosis. Study participants underwent neuropsychological testing involving measures of attention, memory, abstraction, visuoconstructive abilities, and executive function. Results Of 138 initial patients, 47 were excluded because of their medical records, three refused to participate, 23 did not attend the consultation, and 32 were excluded because of having Beck Depression Inventory (BDI) scores >11. In all, 33 patients underwent neuropsychological testing; however, three were excluded because of having hypothyroidism, and one was excluded because of having a cobalamin deficiency. For the control group, of the 33 healthy individuals that were selected, four were excluded because of having BDI scores >11. Thus, the final analysis included 29 HCV patients and 29 control participants. The groups did not differ in education, age, or gender. No statistically significant differences were found between the groups regarding cognitive performance. Conclusions In this study using strict selection criteria, there was no evidence of an association between HCV infection and cognitive impairment.
引用
收藏
页码:433 / 439
页数:7
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