Association between a frequent variant of the FTO gene and anthropometric phenotypes in Brazilian children

被引：28

作者：

da Silva, Carmela Farias ^{[1
]}

Zandona, Marilia Remuzzi ^{[2
]}

Vitolo, Marcia Regina ^{[2
]}

Campagnolo, Paula Dal Bo ^{[2
]}

Rotta, Liane Nanci ^{[2
]}

Almeida, Silvana ^{[2
]}

Mattevi, Vanessa Sune ^{[1
,2
,3
]}

机构：

[1] Univ Fed Ciencias Saude Porto Alegre, Programa Posgrad Patol, Porto Alegre, RS, Brazil

[2] Univ Fed Ciencias Saude Porto Alegre, Programa Posgrad Ciencias Saude, Porto Alegre, RS, Brazil

[3] Univ Fed Ciencias Saude Porto Alegre, BR-90050170 Porto Alegre, RS, Brazil

来源：

BMC MEDICAL GENETICS | 2013年 / 14卷

关键词：

Childhood obesity; FTO gene and genetic susceptibility; BODY-MASS INDEX; OBESITY-ASSOCIATED GENE; FAT MASS; WAIST CIRCUMFERENCE; PHYSICAL-ACTIVITY; SOUTHERN BRAZIL; ADULT OBESITY; ENERGY-INTAKE; POPULATION; POLYMORPHISM;

D O I：

10.1186/1471-2350-14-34

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Our goal was to analyze the association of the fat mass and obesity-associated (FTO) gene rs9939609 variant (T/A) with the anthropometric and dietary intake phenotypes related to obesity in Brazilian children. Methods: We analyzed the association of this single nucleotide polymorphism (SNP) with phenotypes related to the accumulation of body mass in a cohort of 348 children followed from the time of birth until 8 years old and then replicated the main findings in an independent schoolchildren sample (n = 615). Results: At the age of 4, we observed a significant association between the A/A genotype and a higher mean BMI Z-score (P = 0.036). At the age of 8, the A/A individuals still presented with a higher BMI Z-score (P = 0.011) and with marginal differences in the volume of subcutaneous fat (P = 0.048). We replicated these findings in the schoolchildren sample, which showed that those with at least one copy of the A allele presented with a higher BMI Z-score (P = 0.029) and volume of subcutaneous fat (P = 0.016). Conclusion: Our results indicate that this FTO variant is associated with increased body mass and subcutaneous fat in Brazilian children beginning at the age of 4.

引用

页数：8