Reciprocal Modulation Between Microglia and Astrocyte in Reactive Gliosis Following the CNS Injury

被引：106

作者：

Gao, Zhongwen ^{[1
,4
]}

Zhu, Qingsan ^{[1
]}

Zhang, Yiping ^{[2
]}

Zhao, Yingzheng ^{[3
]}

Cai, Lu ^{[4
]}

Shields, Christopher B. ^{[2
]}

Cai, Jun ^{[4
]}

机构：

[1] Jilin Univ, Dept Spine Surg, Hosp 1, Changchun 130021, Jilin, Peoples R China

[2] Norton Healthcare, Norton Neurosci Inst, Norton, KY 40202 USA

[3] Wenzhou Med Coll, Wenzhou City 325035, Zhejiang, Peoples R China

[4] Univ Louisville, Sch Med, Kosair Childrens Hosp, Res Inst,Dept Pediat, Louisville, KY 40202 USA

来源：

MOLECULAR NEUROBIOLOGY | 2013年 / 48卷 / 03期

关键词：

Reactive gliosis; Glial scar; Microglia; Astrocyte; Central nervous system; SPINAL-CORD-INJURY; CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; CHONDROITIN SULFATE PROTEOGLYCANS; IMPROVES FUNCTIONAL RECOVERY; GROWTH-FACTOR ALPHA; NEUROPATHIC PAIN; GLIAL-CELLS; MULTIPLE-SCLEROSIS; BRAIN-INJURY;

D O I：

10.1007/s12035-013-8460-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reactive gliosis, also known as glial scar formation, is an inflammatory response characterized by the proliferation of microglia and astrocytes as well as astrocytic hypertrophy following injury in the central nervous system (CNS). The glial scar forms a physical and molecular barrier to isolate the injured area from adjacent normal nervous tissue for re-establishing the integrity of the CNS. It prevents the further spread of cellular damage but represents an obstacle to regrowing axons. In this review, we integrated the current findings to elucidate the tightly reciprocal modulation between activated microglia and astrocytes in reactive gliosis and proposed that modification of cellular response to the injury or cellular reprogramming in the glial scar could lead advances in axon regeneration and functional recovery after the CNS injury.

引用

页码：690 / 701

页数：12

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