Base-Catalyzed Electrophilic Trifluoromethylthiolation of Terminal Alkynes

被引：133
作者：
Alazet, Sebastien [1 ,2 ]
Zimmer, Luc [2 ,3 ]
Billard, Thierry [1 ,2 ]
机构：
[1] Univ Lyon 1, CNRS, UMR 5246, Inst Chem & Biochem,ICMBS, 43 Bd 11 Novembre 1918, F-69622 Villeurbanne, France
[2] Grp Hosp Est, CERMEP In Vivo Imaging, F-69003 Lyon, France
[3] Grp Hosp Est, Lyon Neurosci Res Ctr, CNRS, INSERM,UMR 5292,UMR 1028, F-69003 Lyon, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 41期
关键词：
alkynes; electrophilic addition; fluorine; trifluoromethanesulfenamide; trifluoromethylthiolation; ARYL FLUOROALKYL SULFIDES; TRIFLUOROMETHANESULFENYL CHLORIDE; CLICK CHEMISTRY; NUCLEOPHILIC TRIFLUOROMETHYLATION; CONVENIENT SYNTHESIS; FLUORINATED ETHERS; DISULFIDES; THIOETHERS; REAGENT; HALIDES;
D O I：
10.1002/anie.201305179
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pin the tail on the alkyne: CF3S- or CF3CF 2S-alkynes can be simply and quickly obtained by mixing terminal alkynes with a trifluoromethanesulfenamide reagent. The reaction uses easy-to-handle reagents, and functions under mild conditions without activation by transition metals. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：10814 / 10817
页数：4
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