Mucosal Insulin Vaccination for Type 1 Diabetes Prevention

被引：7

作者：

Bonifacio, E. ^{[1
]}

Achenbach, P. ^{[2
]}

Pan, L. ^{[2
]}

Ziegler, A. -G. ^{[2
]}

机构：

[1] Tech Univ Dresden, Ctr Biotechnol, CRTD, D-01307 Dresden, Germany

[2] Diabet Res Inst, Munich, Germany

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2008年 / 116卷

关键词：

insulin; oral vaccination; intranasal insulin; type; 1; diabetes; autoimmunity; autoantigen; mucosal immunity; genetic prediction of type 1 diabetes;

D O I：

10.1055/s-2008-1081484

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mucosal administration of autoantigen, if efficacious, is an attractive therapeutic approach for prevention of type 1 diabetes. It can prevent or delay autoimmune diabetes in animal models, but although Shown to be safe has not yet been proven effective in human studies. Efficacy may depend upon the dose and route at which antigen is administered, the stage in type 1 diabetes pathogenesis at which treatment is initiated, and the Study cohort that is treated. Here we address these issues and propose a clinical translation possibility for mucosil insulin administration in genetically at risk individuals.

引用

页码：S26 / S29

页数：4

共 45 条

[1] Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes [J].

Achenbach, P ;

Koczwara, K ;

Knopff, A ;

Naserke, H ;

Ziegler, AG ;

Bonifacio, E .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (04) :589-597

[2] Extreme genetic risk for type 1A diabetes [J].

Aly, Theresa A. ;

Ide, Akane ;

Jahromi, Mohamed M. ;

Barker, Jennifer M. ;

Fernando, Maria S. ;

Babu, Sunanda R. ;

Yu, Liping ;

Miao, Dongmei ;

Erlich, Henry A. ;

Fain, Pamela R. ;

Barriga, Katherine J. ;

Norris, Jill M. ;

Rewers, Marian J. ;

Eisenbarth, George S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (38) :14074-14079

[3] Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health [J].

Arif, S ;

Tree, TI ;

Astill, TP ;

Tremble, JM ;

Bishop, AJ ;

Dayan, CM ;

Roep, BO ;

Peakman, M .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 113 (03) :451-463

[4] Effect of oral insulin on insulin autoantibody levels in the Diabetes Prevention Trial Type 1 oral insulin study [J].

Barker, J. M. ;

McFann, K. K. ;

Orban, T. .

DIABETOLOGIA, 2007, 50 (08) :1603-1606

[5] Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes Autoimmunity Study in the Young (DAISY) [J].

Barker, JM ;

Barriga, KJ ;

Yu, LP ;

Miao, DM ;

Erlich, HA ;

Norris, JM ;

Eisenbarth, GS ;

Rewers, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (08) :3896-3902

[6] ORAL-ADMINISTRATION OF HUMAN INSULIN TO NOD MICE GENERATES CD4(+) T-CELLS THAT SUPPRESS ADOPTIVE TRANSFER OF DIABETES [J].

BERGEROT, I ;

FABIEN, N ;

MAGUER, V ;

THIVOLET, C .

JOURNAL OF AUTOIMMUNITY, 1994, 7 (05) :655-663

[7] IDDMI and multiple family history of type 1 diabetes combine to identify neonates at high risk for type 1 diabetes [J].

Bonifacio, E ;

Hummel, M ;

Walter, M ;

Schmid, S ;

Ziegler, AG .

DIABETES CARE, 2004, 27 (11) :2695-2700

[8] Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs [J].

Bresson, D ;

Togher, L ;

Rodrigo, E ;

Chen, YL ;

Bluestone, JA ;

Herold, KC ;

von Herrath, M .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (05) :1371-1381

[9] Oral insulin administration and residual β-cell function in recent-onset type 1 diabetes:: a multicentre randomised controlled trial [J].

Chaillous, L ;

Lefèvre, H ;

Thivolet, C ;

Boitard, C ;

Lahlou, N ;

Atlan-Gepner, C ;

Bouhanick, B ;

Mogenet, A ;

Nicolino, M ;

Carel, JC ;

Lecomte, P ;

Maréchaud, R ;

Bougnères, P ;

Charbonnel, B ;

Saï, P .

LANCET, 2000, 356 (9229) :545-549

[10] Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody [J].

Colman, PG ;

Steele, C ;

Couper, JJ ;

Beresford, SJ ;

Powell, T ;

Kewming, K ;

Pollard, A ;

Gellert, S ;

Tait, B ;

Honeyman, M ;

Harrison, LC .

DIABETOLOGIA, 2000, 43 (02) :203-209

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