Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil

被引：3

作者：

Marx, Camila ^{[1
]}

Gregianini, Tatiana Schaeffer ^{[2
]}

Moreira Lehmann, Fernanda Kieling ^{[1
]}

Lunge, Vagner Ricardo ^{[1
,3
]}

de Carli, Silvia ^{[1
]}

Dambros, Bibiana Paula ^{[2
]}

Tumioto, Gabriela Luchiari ^{[2
]}

Seadi, Claudete ^{[2
]}

Kazantzi Fonseca, Andre Salvador ^{[3
]}

Ikuta, Nilo ^{[1
,3
]}

机构：

[1] Univ Luterana Brasil, Canoas, RS, Brazil

[2] Lab Cent Saude Publ Rio Grande do Sul, Porto Alegre, RS, Brazil

[3] Simbios Biotecnol, Cachoeirinha, RS, Brazil

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2013年 / 108卷 / 03期

关键词：

influenza A(H1N1)pmd09; resistance; oseltamivir; H1N1; INFECTIONS;

D O I：

10.1590/S0074-02762013000300021

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.

引用

页码：392 / 394

页数：3

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