Paget's Disease of Bone

被引：102

作者：

Ralston, Stuart H. ^{[1
]}

机构：

[1] Univ Edinburgh, Western Gen Hosp, Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2013年 / 368卷 / 07期

关键词：

GENOME-WIDE ASSOCIATION; ZOLEDRONIC ACID; BISPHOSPHONATE THERAPY; SINGLE INFUSION; RISK-FACTORS; MANAGEMENT; ALENDRONATE; ETIDRONATE; FRACTURES; TRIAL;

D O I：

10.1056/NEJMcp1204713

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 73-year-old man presents with a 5-year history of low back pain that is exacerbated by standing. During the past year, pain has developed in his buttocks and legs when he walks, and it is not relieved by acetaminophen. The neurologic examination is unremarkable. Radiographs of the spine show coarsening of the trabecular pattern in several lumbar and lower thoracic vertebrae and expansion of several lumbar vertebral bodies. The total serum alkaline phosphatase level is 350 U per liter (reference range, 40 to 125); the results of liver-function tests and other routine laboratory tests are normal. How should he be further evaluated and treated?

引用

页码：644 / 650

页数：7

共 47 条

[1] Adverse Effects of Bisphosphonates [J].

Abrahamsen, Bo .

CALCIFIED TISSUE INTERNATIONAL, 2010, 86 (06) :421-435

[2] Genome-wide association identifies three new susceptibility loci for Paget's disease of bone [J].

Albagha, Omar M. E. ;

Wani, Sachin E. ;

Visconti, Micaela R. ;

Alonso, Nerea ;

Goodman, Kirsteen ;

Brandi, Maria Luisa ;

Cundy, Tim ;

Chung, Pui Yan Jenny ;

Dargie, Rosemary ;

Devogelaer, Jean-Pierre ;

Falchetti, Alberto ;

Fraser, William D. ;

Gennari, Luigi ;

Gianfrancesco, Fernando ;

Hooper, Michael J. ;

Van Hul, Wim ;

Isaia, Gianluca ;

Nicholson, Geoff C. ;

Nuti, Ranuccio ;

Papapoulos, Socrates ;

del Pino Montes, Javier ;

Ratajczak, Thomas ;

Rea, Sarah L. ;

Rendina, Domenico ;

Gonzalez-Sarmiento, Rogelio ;

Di Stefano, Marco ;

Ward, Lynley C. ;

Walsh, John P. ;

Ralston, Stuart H. .

NATURE GENETICS, 2011, 43 (07) :685-U104

[3] Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone [J].

Albagha, Omar M. E. ;

Visconti, Micaela R. ;

Alonso, Nerea ;

Langston, Anne L. ;

Cundy, Tim ;

Dargie, Rosemary ;

Dunlop, Malcolm G. ;

Fraser, William D. ;

Hooper, Michael J. ;

Isaia, Gianluca ;

Nicholson, Geoff C. ;

del Pino Montes, Javier ;

Gonzalez-Sarmiento, Rogelio ;

di Stefano, Marco ;

Tenesa, Albert ;

Walsh, John P. ;

Ralston, Stuart H. .

NATURE GENETICS, 2010, 42 (06) :520-U26

[4] MUSCULOSKELETAL MANIFESTATIONS OF PAGETS-DISEASE OF BONE [J].

ALTMAN, RD .

ARTHRITIS AND RHEUMATISM, 1980, 23 (10) :1121-1127

[5]

[Anonymous], 2004, J BONE MINER RES, V19, P566

[6]

BOYCE BF, 1984, LANCET, V1, P821

[7] Paget's Disease of Bone: Evidence for Complex Pathogenetic Interactions [J].

Chung, Pui Yan Jenny ;

Van Hul, Wim .

SEMINARS IN ARTHRITIS AND RHEUMATISM, 2012, 41 (05) :619-641

[8] A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice [J].

Daroszewska, Anna ;

van't Hof, Robert J. ;

Rojas, Javier A. ;

Layfield, Robert ;

Landao-Basonga, Euphemie ;

Rose, Lorraine ;

Rose, Ken ;

Ralston, Stuart H. .

HUMAN MOLECULAR GENETICS, 2011, 20 (14) :2734-2744

[9] RHEUMATIC MANIFESTATIONS OF PAGETS-DISEASE OF BONE [J].

FRANCK, WA ;

BRESS, NM ;

SINGER, FR ;

KRANE, SM .

AMERICAN JOURNAL OF MEDICINE, 1974, 56 (05) :592-603

[10] PAGETS-DISEASE OF BONE - CLINICAL AND GENETIC STUDY [J].

GALBRAITH, HJB ;

EVANS, EC ;

LACEY, J .

POSTGRADUATE MEDICAL JOURNAL, 1977, 53 (615) :33-39

← 1 2 3 4 5 →