Knockdown of Aurora-B inhibits the growth of non-small cell lung cancer A549 cells

被引：9
作者：
Yu, Jing Jing [1 ]
Zhou, Long Dian [2 ]
Zhao, Tian Tian [1 ]
Bai, Wei [1 ]
Zhou, Jing [1 ]
Zhang, Wei [1 ]
机构：
[1] Nanchang Univ, Affiliated Hosp 1, Dept Resp Med, Nanchang 330006, Jiangxi, Peoples R China
[2] Nanchang Univ, Affiliated Hosp 1, Dept Orthoped, Nanchang 330006, Jiangxi, Peoples R China
来源：
ONCOLOGY LETTERS | 2015年 / 10卷 / 03期
基金：
中国国家自然科学基金;
关键词：
non-small cell lung cancer; Aurora-B; apoptosis; growth; PI3K/AKT signaling pathway; POOR-PROGNOSIS; EXPRESSION; PROLIFERATION; OSTEOSARCOMA; PREDICTOR; CARCINOMA; KINASES; PATHWAY;
D O I：
10.3892/ol.2015.3467
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Elevated expression of Aurora-B affects cell apoptosis and proliferation in a variety of solid tumors. However, the role of Aurora-B has been poorly evaluated in non-small cell lung cancer (NSCLC). In the present study, it was found that Aurora-B was overexpressed in tissue specimens obtained from 174 patients with lung cancer. It was also demonstrated that knockdown of Aurora-B induces apoptosis and inhibits the growth of lung cancer A549 cells in vitro and in vivo. Furthermore, it was found that silencing Aurora-B decreased the activity of the phosphoinositide 3-kinase (PI3K)/AKT pathway. Therefore, it was concluded that knockdown of Aurora-B induces apoptosis and inhibits growth in NSCLC A549 cells, in addition to inhibiting the activity of the PI3K/AKT signaling pathway. Targeting Aurora-B may provide a novel target for lung cancer therapy.
引用
收藏
页码：1642 / 1648
页数：7
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