Umbilical cord-derived mesenchymal stem cells in neurodegenerative disorders: from literature to clinical practice

被引：44
作者：
Reyhani, Samira [1 ]
Abbaspanah, Bahareh [2 ]
Mousavi, Seyed Hadi [3 ]
机构：
[1] Univ Tehran Med Sci, Sch Allied Med Sci, Dept Lab Sci, Tehran 1417744361, Iran
[2] Royan Stem Cell Technol Co, Cord Blood Bank, Tehran 1417744361, Iran
[3] Univ Tehran Med Sci, Sch Allied Med Sci, Dept Hematol, Tehran 1417744361, Iran
来源：
REGENERATIVE MEDICINE | 2020年 / 15卷 / 04期
关键词：
Alzheimer's disease; amyotrophic lateral sclerosis; cerebral palsy; Huntington disease; multiple sclerosis; neurodegenerative disease; Parkinson's disease; spinal cord injury; stem cell therapies; umbilical cord mesenchymal stem cells; AMYOTROPHIC-LATERAL-SCLEROSIS; STROMAL CELLS; PARKINSONS-DISEASE; RAT MODEL; FUNCTIONAL RECOVERY; DOPAMINERGIC CELLS; MOUSE MODEL; IN-VITRO; TRANSPLANTATION; INJURY;
D O I：
10.2217/rme-2019-0119
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Mesenchymal stem cells (MSCs) have provided a promising tool for cell therapy. Umbilical cord (UC) is one of the best sources of MSCs since its collection is noninvasive, and effortless, and the cells from this source are more capable and prolific. It has been proven that the differentiation, migration and protective properties of UC-MSCs are superior compared with other kinds of stem cells. Moreover, incurable neurodegenerative diseases, such as Alzheimer's disease, multiple sclerosis, Parkinson's disease and Huntington, encourage scientists to apply UC-MSCs transplantation in order to find a definite treatment. This review will focus on the preclinical and clinical use of mesenchymal stem cells derived from human umbilical cord in the treatment of neurodegenerative disorders.
引用
收藏
页码：1561 / 1578
页数：18
相关论文
共 93 条
[1]   Advances in perinatal stem cells research: a precious cell source for clinical applications [J].
Abbaspanah, Bahareh ;
Momeni, Maryam ;
Ebrahimi, Marzieh ;
Mousavi, Seyed Hadi .
REGENERATIVE MEDICINE, 2018, 13 (05) :595-610
[2]  
Aliaghaei A, 2016, ARCH IRAN MED, V19, P561, DOI 0161908/AIM.008
[3]  
Allers C, 2014, REGEN MED, V9, P637, DOI [10.2217/RME.14.30, 10.2217/rme.14.30]
[4]   2018 Alzheimer's disease facts and figures [J].
不详 .
ALZHEIMERS & DEMENTIA, 2018, 14 (03) :367-425
[5]  
Alzheimer's Association, 2016, Alzheimers Dement, V12, P459
[6]  
[Anonymous], 2013, MATH PROBL ENG
[7]  
Bao CS, 2018, EUR REV MED PHARMACO, V22, P6436, DOI 10.26355/eurrev_201810_16056
[8]   Umbilical cord: an unlimited source of cells differentiable towards dopaminergic neurons [J].
Boroujeni, Mahdi Eskandarian ;
Gardaneh, Mossa .
NEURAL REGENERATION RESEARCH, 2017, 12 (07) :1186-1192
[9]  
Calderon-Garcidueñas AL, 2018, HAND CLINIC, V145, P325, DOI 10.1016/B978-0-12-802395-2.00023-7
[10]  
Capriotti Teri, 2016, Home Healthc Now, V34, P300, DOI 10.1097/NHH.0000000000000398
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