Reward Contingencies Improve Goal-Directed Behavior by Enhancing Posterior Brain Attentional Regions and Increasing Corticostriatal Connectivity in Cocaine Addicts

被引:7
作者
Rosell-Negre, Patricia [1 ]
Bustamante, Juan-Carlos [2 ]
Fuentes-Claramonte, Paola [1 ,3 ]
Costumero, Victor [1 ]
Llopis-Llacer, Juan-Jose [4 ]
Barros-Loscertales, Alfonso [1 ]
机构
[1] Univ Jaume 1, Dept Psicol Basica Clin & Psicobiol, Castellon de La Plana, Castello De La, Spain
[2] Univ Zaragoza, Dept Psicol & Sociol, Zaragoza, Zaragoza, Spain
[3] FIDMAG Germanes Hosp Res Fdn Barcelona, Cataluna, Spain
[4] Conselleria Sanitat, Hosp Gen Univ, Unidad Conductas Adict, Castellon De La Plana, Spain
来源
PLOS ONE | 2016年 / 11卷 / 12期
关键词
IMPAIRED INHIBITORY CONTROL; STROOP-LIKE TASK; COGNITIVE CONTROL; PREFRONTAL CORTEX; DECISION-MAKING; DORSAL STRIATUM; PSYCHOPHYSIOLOGICAL INTERACTIONS; DEFICIT/HYPERACTIVITY DISORDER; FUNCTIONAL CONNECTIVITY; RESPONSE-INHIBITION;
D O I
10.1371/journal.pone.0167400
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The dopaminergic system provides the basis for the interaction between motivation and cognition. It is triggered by the possibility of obtaining rewards to initiate the neurobehavioral adaptations necessary to achieve them by directing the information from motivational circuits to cognitive and action circuits. In drug addiction, the altered dopamine (DA) modulation of the meso-cortico-limbic reward circuitry, such as the prefrontal cortex (PFC), underlies the disproportionate motivational value of drug use at the expense of other non drug reinforcers and the user's loss of control over his/her drug intake. We examine how the magnitude of the reward affects goal-directed processes in healthy control (HC) subjects and abstinent cocaine dependent (ACD) patients by using functional magnetic resonance imaging (fMRI) during a counting Stroop task with blocked levels of monetary incentives of different magnitudes ((sic)0, (sic)0.01, (sic)0.5, (sic)1 or (sic)1.5). Our results showed that increasing reward magnitude enhances (1) performance facilitation in both groups; (2) left dorsolateral prefrontal cortex (DLPFC) activity in HC and left superior occipital cortex activity in ACD; and (3) left DLPFC and left putamen connectivity in ACD compared to HC. Moreover, we observed that (4) dorsal striatal and pallidum activity was associated with craving and addiction severity during the parametric increases in the monetary reward. In conclusion, the brain response to gradients in monetary value was different in HC and ACD, but both groups showed improved task performance due to the possibility of obtaining greater monetary rewards.
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页数:22
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