A new jasmonic acid stereoisomeric derivative induces apoptosis via reactive oxygen species in human prostate cancer cells

被引：16

作者：

Russo, Alessandra ^{[1
]}

Espinoza, C. Luis ^{[2
]}

Caggia, Silvia ^{[3
]}

Garbarino, Juan A. ^{[2
]}

Pena-Cortes, Hugo ^{[4
]}

Carvajal, T. Marcela ^{[4
]}

Cardile, Venera ^{[3
]}

机构：

[1] Univ Catania, Biochem Sect, Dept Drug Sci, I-95125 Catania, Italy

[2] Univ TF Santa Maria, Dept Chem, Valparaiso, Chile

[3] Univ Catania, Dept Biomed Sci, I-95125 Catania, Italy

[4] Univ Tecn Federico Santa Maria, Ctr Biotecnol D Alkalay L, Valparaiso, Chile

来源：

CANCER LETTERS | 2012年 / 326卷 / 02期

关键词：

Jasmonate family; Biotransformations; Prostate cancer cells; Apoptosis; Reactive oxygen species; OXIDATIVE STRESS; GENE-EXPRESSION; DEATH; NECROSIS; ACTIVATION; INHIBITION; INDUCTION; CARCINOMA; PROLIFERATION; BIOSYNTHESIS;

D O I：

10.1016/j.canlet.2012.08.025

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With the aim of identifying novel agents with antigrowth and pro-apoptotic activity on prostate cancer cells, in the present study, we evaluated the effect of a (-)-jasmonic acid derivative, the 3-hydroxy-2(S)(2Z-butenyl)-cyclopentane-1(S)-acetic acid, obtained by biotransformation, on cell growth in androgen-sensitive (LNCaP) and androgen-insensitive (DU-145) human prostate cancer cells. The results obtained show that the new compound was able to inhibit the growth of both prostate cancer cells. In addition, our data seem to indicate that the apoptosis evocated by this new molecule, at least in part, appears to be associated with an increase of reactive oxygen species (ROS) production. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：199 / 205

页数：7

共 53 条

[1]

Arceci R J, 1995, Curr Opin Hematol, V2, P268

[2] Apoptosis/necrosis switch in two different cancer cell lines:: Influence of benzoquinone- and hydrogen peroxide-induced oxidative stress intensity, and glutathione [J].