SF3B1 Mutations in CLL Are Equivalent to p53/ATM Dysfunction and Cause Defective Puma Upregulation in Response to Chemotherapy

被引:4
|
作者
te Raa, Doreen [1 ]
Derks, Ingrid A. M. [1 ]
Luijks, Dieuwertje M. [1 ]
van Laar, Jacoline [1 ]
Monsuur, Hanneke [1 ]
Oldreive, Ceri [2 ]
Jethwa, Alexander [3 ,4 ]
Huellein, Jennifer [3 ,4 ]
Stankovic, Tatjana [2 ]
Zenz, Thorsten [5 ]
Van Oers, Marinus H. J. [1 ]
Kater, Arnon P. [1 ]
Eldering, Eric [1 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Birmingham, Sch Canc Sci, Birmingham, W Midlands, England
[3] Natl Ctr Tumor Dis, Dept Translat Oncol, Heidelberg, Germany
[4] German Canc Res Ctr, Heidelberg, Germany
[5] Heidelberg Univ, Heidelberg, Germany
关键词
D O I
10.1182/blood.V120.21.711.711
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
711
引用
收藏
页数:2
相关论文
共 50 条
  • [41] SF3B1 Mutations and Not TP53 Are Associated with Poor Outcomes in Patients with Del(5q) Myelodysplastic Syndromes (MDS)
    Chan, Onyee
    Al Ali, Najla
    Sallman, David A.
    Padron, Eric
    Lancet, Jeffrey E.
    Komrokji, Rami
    BLOOD, 2020, 136
  • [42] Somatic mutations in SF3B1 aberrant-negative MDS-RS most commonly involved in TP53 genes
    Li, Xiao
    Xu, Feng
    Wu, Ling-Yun
    Guo, Juan
    He, Qi
    Zhang, Zheng
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2022, 26 (12) : 3586 - 3589
  • [43] Higher Percentages of Ring Sideroblasts and SF3B1 Mutations in Patients with AML Correlate with Mutations in TP53 and Adverse Cytogenetics, but Have No Independent Impact on Outcome
    Martin-Cabrera, Pedro
    Jeromin, Sabine
    Alpermann, Tamara
    Perglerova, Karolina
    Haferlach, Claudia
    Kern, Wolfgang
    Haferlach, Torsten
    BLOOD, 2015, 126 (23)
  • [44] SF3B1, NOTCH1 and TP53 Mutations Do Not Affect the Outcome of Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for Chronic Lymphocytic Leukemia (CLL): 6-Year Follow-up of the Gcllsg CLL3X Trial
    Dreger, Peter
    Schnaiter, Andrea
    Rossi, Marianna
    Paschka, Peter
    Buehler, Andreas
    Zenz, Thorsten
    Dietrich, Sascha
    Boettcher, Sebastian
    Bunjes, Donald
    Stadler, Michael
    Uharek, Lutz
    Scheid, Christof
    Hegenbart, Ute
    Hallek, Michael
    Kneba, Michael
    Schmitz, Norbert
    Doehner, Hartmut
    Stilgenbauer, Stephan
    BLOOD, 2012, 120 (21)
  • [45] Mutation frequencies of NOTCH1, SF3B1, MYD88, TP53 and POT1 in a cohort of CLL patients from the Region of Southern Denmark
    Kristensen, Louise
    Kristensen, Thomas Kielsgaard
    Royo, Cristina
    Abildgaard, Niels
    Campo, Elias
    Moller, Michael Boe
    APMIS, 2014, 122 : 10 - 11
  • [46] On the way towards a ‘CLL prognostic index’: focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort
    D Cortese
    L-A Sutton
    N Cahill
    K E Smedby
    C Geisler
    R Gunnarsson
    G Juliusson
    L Mansouri
    R Rosenquist
    Leukemia, 2014, 28 : 710 - 713
  • [47] Relative Impact of NOTCH1/SF3B1 Mutations, Complex Karyotype and TP53 Disruption in the Prognosis of Chronic Lymphocytic Leukemia Patients.
    Ysebaert, Loic
    Struski, Stephanie
    Prade, Nais
    Guieze, Romain
    Laurent, Guy
    Delabesse, Eric
    BLOOD, 2012, 120 (21)
  • [48] NOTCH1, SF3B1, BIRC3 and TP53 mutations in patients with chronic lymphocytic leukemia undergoing first-line treatment: correlation with biological parameters and response to treatment
    Chiaretti, Sabina
    Marinelli, Marilisa
    Del Giudice, Ilaria
    Bonina, Silvia
    Piciocchi, Alfonso
    Messina, Monica
    Vignetti, Marco
    Rossi, Davide
    Di Maio, Valeria
    Mauro, Francesca Romana
    Guarini, Anna
    Gaidano, Gianluca
    Foa, Robin
    LEUKEMIA & LYMPHOMA, 2014, 55 (12) : 2785 - 2792
  • [49] On the way towards a 'CLL prognostic index': focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort
    Cortese, D.
    Sutton, L-A
    Cahill, N.
    Smedby, K. E.
    Geisler, C.
    Gunnarsson, R.
    Juliusson, G.
    Mansouri, L.
    Rosenquist, R.
    LEUKEMIA, 2014, 28 (03) : 710 - 713
  • [50] Integrated Genomic and Proteomic Analysis of Murine CLL-like Cells Reveals SF3B1 Mutation to Impact DNA Damage Response and BCR Signaling
    Wang, Lili
    Yin, Shanye
    Martinez, Aina Zurita
    Regis, Fara Faye
    Brooks, Angela
    Herman, Sarah E. M.
    Ten Hacken, Elisa
    Obeng, Esther
    Campagna, Dean
    Fleming, Mark D.
    Ebert, Benjamin L.
    Wiestner, Adrian
    Leshchiner, Ignaty
    Getz, Gad
    Carrasco, Ruben D.
    Wu, Catherine J.
    BLOOD, 2018, 132