Intestinal microbial metabolites in human metabolism and type 2 diabetes

被引：58

作者：

Herrema, Hilde ^{[1
]}

Niess, Jan Hendrik ^{[2
,3
,4
]}

机构：

[1] Univ Amsterdam, Dept Expt Vasc Med, Locat AMC, Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Basel, Dept Biomed, Hebelstr 20, CH-4031 Basel, Switzerland

[3] Univ Ctr Gastrointestinal & Liver Dis, St Clara Hosp, Basel, Switzerland

[4] Univ Hosp Basel, Basel, Switzerland

来源：

DIABETOLOGIA | 2020年 / 63卷 / 12期

基金：

瑞士国家科学基金会;

关键词：

Intestinal barrier; Metabolites; Microbiome; Review; The metabolic syndrome; Type; 2; diabetes; CHAIN FATTY-ACIDS; TRIMETHYLAMINE N-OXIDE; HUMAN GUT MICROBIOME; INSULIN SENSITIVITY; PEPTIDE-1; SECRETION; NUCLEAR RECEPTOR; BETA-CELLS; OBESITY; DIET; MOUSE;

D O I：

10.1007/s00125-020-05268-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Humans with the metabolic syndrome and type 2 diabetes have an altered gut microbiome. Emerging evidence indicates that it is not only the microorganisms and their structural components, but also their metabolites that influences the host and contributes to the development of the metabolic syndrome and type 2 diabetes. Here, we discuss some of the mechanisms underlying how microbial metabolites are recognised by the host or are further processed endogenously in the context of type 2 diabetes. We discuss the possibility that gut-derived microbial metabolites fuel the development of the metabolic syndrome and type 2 diabetes.

引用

页码：2533 / 2547

页数：15

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